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2019

Brecht, Karin and Kirchhofer, Carla and Bouitbir, Jamal and Trapani, Francesca and Keiser, Jennifer and Krähenbühl, Stephan. (2019) Exogenous iron increases fasciocidal activity and hepatocellular toxicity of the synthetic endoperoxides OZ78 and MT04. International Journal of Molecular Sciences, 20 (19). p. 4880.

Bouitbir, Jamal and Sanvee, Gerda M. and Panajatovic, Miljenko V. and Singh, François and Krähenbühl, Stephan. (2019) Mechanisms of statin-associated skeletal muscle-associated symptoms. Pharmacological research (154). p. 104201.

Sanvee, Gerda M. and Panajatovic, Miljenko V. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle. Biochemical pharmacology, 164. pp. 23-33.

Singh, François and Zoll, Joffrey and Duthaler, Urs and Charles, Anne-Laure and Panajatovic, Miljenko V. and Laverny, Gilles and McWilliams, Thomas G. and Metzger, Daniel and Geny, Bernard and Krähenbühl, Stephan and Bouitbir, Jamal. (2019) PGC-1β modulates statin-associated myotoxicity in mice. Archives of Toxicology, 93 (2). pp. 487-504.

Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2019) Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. Scientific reports, 9 (1). p. 7409.

Bouitbir, Jamal and Alshaikhali, Abdallah and Panajatovic, Miljenko V. and Abegg, Vanessa F. and Paech, Franziska and Krähenbühl, Stephan. (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts. Toxicology, 426. p. 152281.

Bühler, Tim and Medinger, Michael and Bouitbir, Jamal and Krähenbühl, Stephan and Leuppi-Taegtmeyer, Anne. (2019) Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient. Frontiers in pharmacology, 10. p. 645.

Zhou, Xun and Luethi, Dino and Sanvee, Gerda M. and Bouitbir, Jamal and Liechti, Matthias E. and Krähenbühl, Stephan. (2019) Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts. International journal of molecular sciences, 20 (7). p. 1561.

2018

Grünig, David and Felser, Andrea and Duthaler, Urs and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicological sciences, 164 (2). pp. 477-488.

Paech, Franziska and Abegg, Vanessa F. and Duthaler, Urs and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology, 409. pp. 13-23.

Paech, Franziska and Mingard, Cécile and Grünig, David and Abegg, Vanessa F. and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology, 395. pp. 34-44.

Mingard, Cécile and Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2018) Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines. Journal of applied toxicology : JAT, 38 (3). pp. 418-431.

2017

Bonifacio, Annalisa and Sanvee, Gerda M. and Brecht, Karin and Kratschmar, Denise V. and Odermatt, Alex and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) IGF-1 prevents simvastatin-induced myotoxicity in C2C12 myotubes. Archives of Toxicology, 91 (5). pp. 2223-2234.

Paech, Franziska and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis. Frontiers in Pharmacology, 8. p. 367.

Grünig, David and Felser, Andrea and Bouitbir, Jamal and Krähenbühl, Stephan. (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicology in Vitro, 42. pp. 337-347.

Haegler, Patrizia and Joerin, Lorenz and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatocellular Toxicity of Imidazole and Triazole Antimycotic Agents. Toxicological sciences, 157 (1). pp. 183-195.

Charles, Anne-Laure and Guilbert, Anne-Sophie and Guillot, Max and Talha, Samy and Lejay, Anne and Meyer, Alain and Kindo, Michel and Wolff, Valérie and Bouitbir, Jamal and Zoll, Joffrey and Geny, Bernard. (2017) Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level. Frontiers in physiology, 8. p. 52.

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Terracciano, Luigi and Krähenbühl, Stephan and Bouitbir, Jamal. (2017) Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice. PLoS One, 12 (1). e0171026.

2016

Novakova, Katerina and Kummer, Oliver and Bouitbir, Jamal and Stoffel, Sonja D. and Hoerler-Koerner, Ulrike and Bodmer, Michael and Roberts, Paul and Urwyler, Albert and Ehrsam, Rolf and Krähenbühl, Stephan. (2016) Effect of l-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. European Journal of Nutrition, 55 (1). pp. 207-217.

Bonifacio, Annalisa and Mullen, Peter J. and Mityko, Ileana Scurtu and Navegantes, Luiz C. and Bouitbir, Jamal and Krähenbühl, Stephan. (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Archives of Toxicology, 90 (1). pp. 203-215.

Bouitbir, Jamal and Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bonifacio, Annalisa and Echaniz-Laguna, Andoni and Geny, Bernard and Krahenbuhl, Stephan and Zoll, Joffrey. (2016) Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle. Antioxidants and Redox Signaling, 24 (2). pp. 84-98.

Bouitbir, Jamal and Haegler, Patrizia and Singh, François and Joerin, Lorenz and Felser, Andrea and Duthaler, Urs and Krähenbühl, Stephan. (2016) Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency. Frontiers in Physiology, 7. p. 345.

2015

Haegler, Patrizia and Grünig, David and Berger, Benjamin and Krähenbühl, Stephan and Bouitbir, Jamal. (2015) Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: a cell model for idiosyncratic toxicity. Toxicology, 336. pp. 48-58.

Roberts, Paul A. and Bouitbir, Jamal and Bonifacio, Annalisa and Singh, François and Kaufmann, Priska and Urwyler, Albert and Krähenbühl, Stephan. (2015) Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency. American Journal of Physiology. Endocrinology and Metabolism, 309 (3). E265-E274.

Bonifacio, Annalisa and Sanvee, Gerda M. and Bouitbir, Jamal and Krähenbühl, Stephan. (2015) The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity. Biochimica et biophysica acta. Molecular cell research, 1853 (8). pp. 1841-1849.

Singh, François and Charles, Anne-Laure and Schlagowski, Anna-Isabel and Bouitbir, Jamal and Bonifacio, Annalisa and Piquard, François and Krähenbühl, Stephan and Geny, Bernard and Zoll, Joffrey. (2015) Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis. Biochimica et biophysica acta. Molecular cell research, 1853 (7). pp. 1574-1585.

2014

Morand, Réjane and Bouitbir, Jamal and Felser, Andrea and Hench, Jürgen and Handschin, Christoph and Frank, Stephan and Krähenbühl, Stephan. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6). pp. 1313-1325.

Felser, Andrea and Stoller, Andrea and Morand, Réjane and Schnell, Dominik and Donzelli, Massimiliano and Terracciano, Luigi and Bouitbir, Jamal and Krähenbühl, Stephan. (2014) Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. Toxicology, 323. pp. 1-9.

Lejay, Anne and Meyer, Alain and Schlagowski, Anna-Isabel and Charles, Anne-Laure and Singh, François and Bouitbir, Jamal and Pottecher, Julien and Chakfé, Nabil and Zoll, Joffrey and Geny, Bernard. (2014) Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscle. The international journal of biochemistry & cell biology, 50. pp. 101-105.

Guillot, Max and Charles, Anne-Laure and Chamaraux-Tran, Thien Nga and Bouitbir, Jamal and Meyer, Alain and Zoll, Joffrey and Schneider, Francis and Geny, Bernard. (2014) Oxidative stress precedes skeletal muscle mitochondrial dysfunction during experimental aortic cross-clamping but is not associated with early lung, heart, brain, liver, or kidney mitochondrial impairment. Journal of vascular surgery, 60 (4). pp. 1043-1051.e5.

2013

Zahno, Anja and Bouitbir, Jamal and Maseneni, Swarma and Lindinger, Peter W. and Brecht, Karin and Krähenbühl, Stephan. (2013) Hepatocellular toxicity of clopidogrel: Mechanisms and risk factors. Free radical biology and medicine, 65. pp. 208-216.

Felser, Andrea and Blum, Kim and Lindinger, Peter W. and Bouitbir, Jamal and Krähenbühl, Stephan. (2013) Mechanisms of hepatocellular toxicity associated with dronedarone--a comparison to amiodarone. Toxicological sciences, 131 (2). pp. 480-490.