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Local but not systemic capillary lactate is a reperfusion biomarker in experimental acute limb ischaemia

Noll, E. and Bouitbir, J. and Collange, O. and Zoll, J. and Charles, A. L. and Thaveau, F. and Diemunsch, P. and Geny, B.. (2012) Local but not systemic capillary lactate is a reperfusion biomarker in experimental acute limb ischaemia. European Journal of Vascular and Endovascular Surgery, 43 (3). pp. 339-340.

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Official URL: https://edoc.unibas.ch/78254/

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Abstract

Systemic capillary lactate, an end product of cellular anaerobic metabolism, has not established credibility in monitoring limb reperfusion. We assessed, in mice, whether local capillary lactate, arising from the reperfused limb, might be a relevant biomarker of reperfusion.; Systemic and local capillary lactate were sampled in the non-ischaemic and in the ischaemic limb. Only local lactate concentrations significantly increased after 2 h of ischaemia and decreased after reperfusion.; Local, but not systemic, capillary lactate appeared as a potential reperfusion biomarker in this experimental acute limb ischaemia model.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften
UniBasel Contributors:Bouitbir, Jamal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1078-5884
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Nov 2020 16:21
Deposited On:03 Nov 2020 16:21

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