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Isoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion

Collange, Olivier and Charles, Anne-Laure and Noll, Eric and Bouitbir, Jamal and Zoll, Joffrey and Piquard, François and Diemunsch, Pierre and Geny, Bernard. (2011) Isoflurane anesthesia preserves liver and lung mitochondrial oxidative capacity after gut ischemia-reperfusion. Anesthesia and Analgesia, 113 (6). pp. 1438-1441.

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Official URL: https://edoc.unibas.ch/78256/

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Abstract

Lung and liver dysfunction is involved in gut ischemia-reperfusion (IR)-induced multiple organ failure. We compared the effects of ketamine and isoflurane on liver and lung mitochondrial oxidative capacity after gut IR.; Adult male Wistar rats were randomized into 4 groups (controls and gut IR receiving either intraperitoneal ketamine or inhaled isoflurane). Maximal oxygen consumption and the activity of respiratory chain complexes were measured on isolated liver and lung mitochondria.; Gut IR significantly impaired liver and lung mitochondrial oxidative capacity when using ketamine but not isoflurane.; Isoflurane preserved liver and lung mitochondrial oxidative capacity after gut IR.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Klinische Pharmakologie > Klinische Pharmakologie (Krähenbühl)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften
UniBasel Contributors:Bouitbir, Jamal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott, Williams & Wilkins
ISSN:0003-2999
e-ISSN:1526-7598
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Nov 2020 16:17
Deposited On:03 Nov 2020 16:17

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