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Suboticki, Tijana and Mitrovic Ajtic, Olivera and Beleslin-Cokic, Bojana B. and Nienhold, Ronny and Diklic, Milos and Djikic, Dragoslava and Lekovic, Danijela and Bulat, Tanja and Markovic, Dragana and Gotic, Mirjana and Noguchi, Constance T. and Schechter, Alan N. and Skoda, Radek C. and Cokic, Vladan P.. (2017) Angiogenic factors are increased in circulating granulocytes and CD34+ cells of myeloproliferative neoplasms. Molecular carcinogenesis, 56 (2). pp. 567-579.

Pastor Loyola, Victor Bengt and Hirabayashi, S. and Karow, Axel and Wehrle, Julius and Kozyra, E. J. and Nienhold, Ronny and Ruzaike, G. and Lebrecht, Dirk and Yoshimi, Ayami and Niewisch, M. and Ripperger, T. and Gohring, Gudrun and Baumann, Irith and Schwarz, S. and Strahm, Brigitte and Flotho, Christian and Skoda, Radek C. and Niemeyer, Charlotte M. and Wlodarski, Marcin W.. (2017) Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants. Leukemia, 31 (3). pp. 759-762.

Lekovic, Danijela and Gotic, Mirjana and Skoda, Radek and Beleslin-Cokic, Bojana and Milic, Natasa and Mitrovic-Ajtic, Olivera and Nienhold, Ronny and Sefer, Dijana and Suboticki, Tijana and Buac, Marijana and Markovic, Dragana and Diklic, Milos and Cokic, Vladan P.. (2017) Bone marrow microvessel density and plasma angiogenic factors in myeloproliferative neoplasms: clinicopathological and molecular correlations. Annals of Hematology, 96 (3). pp. 393-404.


Grisouard, Jean and Li, Sai and Kubovcakova, Lucia and Rao, Tata Nageswara and Meyer, Sara C. and Lundberg, Pontus and Hao-Shen, Hui and Romanet, Vincent and Murakami, Masato and Radimerski, Thomas and Dirnhofer, Stephan and Skoda, Radek C.. (2016) JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis. Blood, 128 (6). pp. 839-851.

Theocharides, A. P. and Lundberg, P. and Lakkaraju, A. K. and Lysenko, V. and Myburgh, R. and Aguzzi, A. and Skoda, R. C. and Manz, M. G.. (2016) Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency. Blood, 127 (25). pp. 3253-3259.


Holbro, Andreas and Skoda, Radek and Lundberg, Pontus and Passweg, Jakob and Buser, Andreas and Lehmann, Thomas. (2015) Erythropoietin receptor mutation--a rush of blood to the head? Annals of hematology, 94 (7). pp. 1229-1231.

Strassel, Catherine and Kubovcakova, Lucia and Mangin, Pierre H. and Ravanat, Catherine and Freund, Monique and Skoda, Radek C. and Denis, Cécile V. and Dupuis, Arnaud and Herbrecht, Raoul and Gachet, Christian and Lanza, François. (2015) Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis. Thrombosis and Haemostasis, 113 (2). pp. 414-425.

Skoda, Radek C. and Duek, Adrian and Grisouard, Jean. (2015) Pathogenesis of myeloproliferative neoplasms. Experimental Hematology, 43 (8). pp. 599-608.

Karow, A. and Nienhold, R. and Lundberg, P. and Peroni, E. and Putti, M. C. and Randi, M. L. and Skoda, Radek C.. (2015) Mutational profile of childhood myeloproliferative neoplasms. Leukemia, 29 (12). pp. 2407-2409.

Hammaren, Henrik M. and Ungureanu, Daniela and Grisouard, Jean and Skoda, Radek C. and Hubbard, Stevan R. and Silvennoinen, Olli. (2015) ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation. Proceedings of the National Academy of Scince of the U.S.A., 112 (15). pp. 4642-4647.

Grisouard, Jean and Shimizu, Takafumi and Duek, Adrian and Kubovcakova, Lucia and Hao-Shen, Hui and Dirnhofer, Stephan and Skoda, Radek C.. (2015) Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN. Blood, 125 (13). pp. 2131-2140.


Hussein, K. and Percy, M. and McMullin, M. F. and Schwarz, J. and Schnittger, S. and Porret, N. and Martinez-Aviles, L. M. and Paricio, B. B. and Giraudier, S. and Skoda, R. and Lippert, E. and Hermouet, S. and Cario, H.. (2014) Clinical utility gene card for: Hereditary thrombocythemia. European journal of human genetics, Vol. 22, H. 2.

Sánchez-Aguilera, Abel and Arranz, Lorena and Martín-Pérez, Daniel and García-García, Andrés and Stavropoulou, Vaia and Kubovcakova, Lucia and Isern, Joan and Martín-Salamanca, Sandra and Langa, Xavier and Skoda, Radek C. and Schwaller, Jürg and Méndez-Ferrer, Simón. (2014) Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell, 15 (6). pp. 791-804.

Arranz, Lorena and Sánchez-Aguilera, Abel and Martín-Pérez, Daniel and Isern, Joan and Langa, Xavier and Tzankov, Alexandar and Lundberg, Pontus and Muntión, Sandra and Tzeng, Yi-Shiuan and Lai, Dar-Ming and Schwaller, Jürg and Skoda, Radek C. and Méndez-Ferrer, Simón. (2014) Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature, 512 (7512). pp. 78-81.

Skoda, Radek C.. (2014) Less Jak2 makes more platelets. Blood, 124 (14). pp. 2168-2169.

Santisakultarm, T. Puifai and Paduano, Claire Q. and Stokol, Tracy and Southard, Teresa L. and Nishimura, Nozomi and Skoda, Radek C. and Olbricht, William L. and Schafer, Andrew I. and Silver, Richard T. and Schaffer, Chris B.. (2014) Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. Journal of thrombosis and haemostasis, 12 (12). pp. 2120-2130.

Lundberg, Pontus and Takizawa, Hitoshi and Kubovcakova, Lucia and Guo, Guoji and Hao-Shen, Hui and Dirnhofer, Stephan and Orkin, Stuart H. and Manz, Markus G. and Skoda, Radek C.. (2014) Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. Journal of experimental medicine, 211 (11). pp. 2213-2230.

Lundberg, Pontus and Nienhold, Ronny and Ambrosetti, Achille and Cervantes, Francisco and Perez-Encinas, Manuel M. and Skoda, Radek C.. (2014) Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms. Blood, 123 (17). pp. 2744-2745.

Lundberg, Pontus and Karow, Axel and Nienhold, Ronny and Looser, Renate and Hao-Shen, Hui and Nissen, Ina and Girsberger, Sabine and Lehmann, Thomas and Passweg, Jakob and Stern, Martin and Beisel, Christian and Kralovics, Robert and Skoda, Radek C.. (2014) Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood, 123 (14). pp. 2220-2228.

Grisouard, Jean and Hao-Shen, Hui and Dirnhofer, Stefan and Wagner, Kay-Uwe and Skoda, Radek C.. (2014) Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. Haematologica, 99 (4). e52-4.

Duek, Adrian and Lundberg, Pontus and Shimizu, Takafumi and Grisouard, Jean and Karow, Axel and Kubovcakova, Lucia and Hao-Shen, Hui and Dirnhofer, Stephan and Skoda, Radek C.. (2014) Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs. Blood, 123 (25). pp. 3943-3950.


Kubovcakova, L. and Lundberg, P. and Grisouard, J. and Hao-Shen, H. and Romanet, V. and Andraos, R. and Murakami, M. and Dirnhofer, S. and Wagner, K. U. and Radimerski, T. and Skoda, R. C.. (2013) Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood, Vol. 121, H. 7. pp. 1188-1199.

Grisouard, J. and Ojeda-Uribe, M. and Looser, R. and Hao-Shen, H. and Lundberg, P. and Duek, A. and Jeandidier, E. and Karow, A. and Skoda, R. C.. (2013) Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia. Blood, Vol. 122, H. 22. pp. 3694-3696.

Girsberger, S. and Karow, A. and Lundberg, P. and Dirnhofer, S. and Lehmann, T. and Passweg, J. R. and Tichelli, A. and Skoda, R. and Rovo, A.. (2013) JAK2 V617F-mutated myeloproliferative neoplasia developing five years after wild-type JAK2 acute myeloid leukemia : a case report. Acta Haematologica, 129 (1). pp. 23-25.


Lai, J. C. and Ponti, S. and Pan, D. and Kohler, H. and Skoda, R. C. and Matthias, P. and Nagamine, Y.. (2012) The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood, Vol. 119, H. 18. pp. 4291-4300.

de Wit, T. D. and Borkhardt, A. and Chomienne, C. and Dohner, H. and Fibbe, W. E. and Foa, R. and Hagenbeek, A. and Skoda, R. C. and Smand, C. R. and Jager, U.. (2012) Raising hematology's European voice: the importance of calling yourself a hematologist. Haematologica, Vol. 97, H. 4. pp. 476-478.


Chagraoui, Hedia and Kassouf, Mira and Banerjee, Sreemoti and Goardon, Nicolas and Clark, Kevin and Atzberger, Ann and Pearce, Andrew C. and Skoda, Radek C. and Ferguson, David J. P. and Watson, Steve P. and Vyas, Paresh and Porcher, Catherine. (2011) SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood, Vol. 118, H. 3. pp. 723-735.

Zhang, G. and Xiang, B. and Dong, A. and Skoda, R. C. and Daugherty, A. and Smyth, S. S. and Du, X. and Li, Z.. (2011) Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood, Vol. 118, H. 13. pp. 3670-3679.

Passamonti, Francesco and Elena, Chiara and Schnittger, Susanne and Skoda, Radek C. and Green, Anthony R. and Girodon, François and Kiladjian, Jean-Jacques and McMullin, Mary Frances and Ruggeri, Marco and Besses, Carles and Vannucchi, Alessandro M. and Lippert, Eric and Gisslinger, Heinz and Rumi, Elisa and Lehmann, Thomas and Ortmann, Christina A. and Pietra, Daniela and Pascutto, Cristiana and Haferlach, Torsten and Cazzola, Mario. (2011) Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations. Blood, Vol. 117, H. 10. pp. 2813-2816.

Skoda, R. C. and Schwaller, J.. (2011) HiJAKing the methylosome in myeloproliferative disorders. Cancer cell, Vol. 19, H. 2. pp. 161-163.

Ungureanu, Daniela and Wu, Jinhua and Pekkala, Tuija and Niranjan, Yashavanthi and Young, Clifford and Jensen, Ole N. and Xu, Chong-Feng and Neubert, Thomas A. and Skoda, Radek C. and Hubbard, Stevan R. and Silvennoinen, Olli. (2011) The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nature structural & molecular biology, Vol. 18, no. 9. pp. 971-976.

Schaub, Franz X. and Lehmann, Thomas and Looser, Renate and Hao-Shen, Hui and Tichelli, Andre and Skoda, Radek C.. (2011) Transition to homozygosity does not appear to provide a clonal advantage to hematopoietic progenitors carrying mutations in TET2. Blood, Vol. 117, H. 6. pp. 2075-2076.


Bertozzi, Cara C. and Schmaier, Alec A. and Mericko, Patricia and Hess, Paul R. and Zou, Zhiying and Chen, Mei and Chen, Chiu-Yu and Xu, Bin and Lu, Min-min and Zhou, Diane and Sebzda, Eric and Santore, Matthew T. and Merianos, Demetri J. and Stadtfeld, Matthias and Flake, Alan W. and Graf, Thomas and Skoda, Radek and Maltzman, Jonathan S. and Koretzky, Gary A. and Kahn, Mark L.. (2010) Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood, Vol. 116, H. 4. pp. 661-670.

Skoda, R. C.. (2010) JAK2 impairs stem cell function? Blood, Vol. 116, H. 9. pp. 1392-1393.

Schaub, Franz X. and Looser, Renate and Li, Sai and Hao-Shen, Hui and Lehmann, Thomas and Tichelli, Andre and Skoda, Radek C.. (2010) Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood, Vol. 115, H. 10. pp. 2003-2007.

Posthuma, Hidde L. A. and Skoda, Radek C. and Jacob, Frank A. and van der Maas, Anthonie P. C. and Valk, Peter J. M. and Posthuma, Eduardus F. M.. (2010) Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis. Blood, Vol. 116, H. 17. pp. 3375-3376.

Skoda, . (2010) Hereditary myeloproliferative disorders. Haematologica, Vol. 95, H. 1. pp. 6-8.


Liu, Kun and Martini, Maurizio and Rocca, Bianca and Amos, Christopher I. and Teofili, Luciana and Giona, Fiorina and Ding, Jianmin and Komatsu, Hirokazu and Larocca, Luigi M. and Skoda, Radek C.. (2009) Evidence for a founder effect of the MPL-S505N mutation in eight Italian pedigrees with hereditary thrombocythemia. Haematologica : journal of hematology, Vol. 94. pp. 1368-1374.

Schaub, Franz X. and Jäger, Roland and Looser, Renate and Hao-Shen, Hui and Hermouet, Sylvie and Girodon, François and Tichelli, Andre and Gisslinger, Heinz and Kralovics, Robert and Skoda, Radek C.. (2009) Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F. Blood : the journal of the American Society of Hematology, Vol. 113. pp. 2022-2027.

Lippert, Eric and Girodon, François and Hammond, Emma and Jelinek, Jaroslav and Reading, N. Scott and Fehse, Boris and Hanlon, Katy and Hermans, Mirjam and Richard, Céline and Swierczek, Sabina and Ugo, Valérie and Carillo, Serge and Harrivel, Véronique and Marzac, Christophe and Pietra, Daniela and Sobas, Marta and Mounier, Morgane and Migeon, Marina and Ellard, Sian and Kröger, Nicolaus and Herrmann, Richard and Prchal, Josef T. and Skoda, Radek C. and Hermouet, Sylvie. (2009) Concordance of assays designed for the quantification of JAK2V617F : a multicenter study. Haematologica : journal of hematology, Vol. 94. pp. 38-45.

Tiedt, Ralph and Coers, Jörn and Ziegler, Sandra and Wiestner, Adrian and Hao-Shen, Hui and Bornmann, Caroline and Schenkel, Johannes and Karakhanova, Svetlana and de Sauvage, Frederic J. and Jackson, Carl W. and Skoda, Radek C.. (2009) Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood : the journal of the American Society of Hematology, Vol. 113. pp. 1768-1777.

Tefferi, Ayalew and Skoda, Radek and Vardiman, James W.. (2009) Myeloproliferative neoplasms : contemporary diagnosis using histology and genetics. Nature reviews . Clinical oncology, Vol. 6. pp. 627-637.

Olcaydu, D. and Skoda, R. C. and Looser, R. and Li, S. and Cazzola, M. and Pietra, D. and Passamonti, F. and Lippert, E. and Carillo, S. and Girodon, F. and Vannucchi, A. and Reading, N. S. and Prchal, J. T. and Ay, C. and Pabinger, I. and Gisslinger, H. and Kralovics, R.. (2009) The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera. Leukemia, Vol. 23, no. 10. pp. 1924-1926.

Goldman, J. M. and Green, A. R. and Holyoake, T. and Jamieson, C. and Mesa, R. and Mughal, T. and Pellicano, F. and Perrotti, D. and Skoda, R. and Vannucchi, A. M.. (2009) Chronic myeloproliferative diseases with and without the Ph chromosome : some unresolved issues. Leukemia, Vol. 23, no. 10. pp. 1708-1715.

Medinger, Michael and Skoda, Radek and Gratwohl, Alois and Theocharides, Alexandre and Buser, Andreas and Heim, Dominik and Dirnhofer, Stephan and Tichelli, André and Tzankov, Alexandar. (2009) Angiogenesis and vascular endothelial growth factor-/receptor expression in myeloproliferative neoplasms: correlation with clinical parameters and JAK2-V617F mutational status. British Journal of Haematology, 146 (2). pp. 150-157.


Liu, K. and Kralovics, R. and Rudzki, Z. and Grabowska, B. and Buser, A. S. and Olcaydu, D. and Gisslinger, H. and Tiedt, R. and Frank, P. and Okoñ, K. and van der Maas, A. P. and Skoda, R. C.. (2008) A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family. Haematologica, Vol. 93, H. 5. pp. 706-714.

Schmitt-Graeff, A. H. and Teo, S. S. and Olschewski, M. and Schaub, F. and Haxelmans, S. and Kirn, A. and Reinecke, P. and Germing, U. and Skoda, R. C.. (2008) JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica, Vol. 93, H. 1. pp. 34-40.

Theocharides, Alexandre and Passweg, Jakob R. and Medinger, Michael and Looser, Renate and Li, Sai and Hao-Shen, Hui and Buser, Andreas S. and Gratwohl, Alois and Tichelli, André and Skoda, Radek C.. (2008) The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders. Haematologica, 93 (12). pp. 1890-1893.

Cross, N. C. P. and Daley, G. Q. and Green, A. R. and Hughes, T. P. and Jamieson, C. and Manley, P. and Mughal, T. and Perrotti, D. and Radich, J. and Skoda, R. and Soverini, S. and Vainchenker, W. and Verstovsek, S. and Villeval, J.-L. and Goldman, J. M.. (2008) BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders : some common and contrasting features. Leukemia, Vol. 22, no. 11. pp. 1975-1989.

Pasqualucci, L. and Li, S. and Meloni, G. and Schnittger, S. and Gattenlohner, S. and Liso, A. and Di Ianni, M. and Martelli, M. P. and Pescarmona, E. and Foa, R. and Haferlach, T. and Skoda, R. C. and Falini, B.. (2008) NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis : de-novo origin? Leukemia, Vol. 22, no. 7. pp. 1459-1463.

Tiedt, Ralph and Hao-Shen, Hui and Sobas, Marta A. and Looser, Renate and Dirnhofer, Stephan and Schwaller, Jürg and Skoda, Radek C.. (2008) Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood, 111 (8). pp. 3931-3940.

Li, Sai and Kralovics, Robert and De Libero, Gennaro and Theocharides, Alexandre and Gisslinger, Heinz and Skoda, Radek C.. (2008) Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. Blood, 111 (7). pp. 3863-3866.

Pietra, Daniela and Li, Sai and Brisci, Angela and Passamonti, Francesco and Rumi, Elisa and Theocharides, Alexandre and Ferrari, Maurizio and Gisslinger, Heinz and Kralovics, Robert and Cremonesi, Laura and Skoda, Radek C. and Cazzola, Mario. (2008) Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood, 111 (3). pp. 1686-1689.

Skoda, Radek C.. (2008) Can we control JAK? Blood, 111 (12). pp. 5419-5420.