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Chronic myeloproliferative diseases with and without the Ph chromosome : some unresolved issues

Goldman, J. M. and Green, A. R. and Holyoake, T. and Jamieson, C. and Mesa, R. and Mughal, T. and Pellicano, F. and Perrotti, D. and Skoda, R. and Vannucchi, A. M.. (2009) Chronic myeloproliferative diseases with and without the Ph chromosome : some unresolved issues. Leukemia, Vol. 23, no. 10. pp. 1708-1715.

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Official URL: http://edoc.unibas.ch/dok/A6007489

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Abstract

Ph-positive chronic myeloid leukemia (CML) and Ph-negative chronic myeloproliferative diseases (MPDs), characterized in many cases by the presence of the JAK2(V617F) mutation, have many features in common and yet also show fundamental differences. In this review, we pose five discrete and related questions relevant to both categories of hematological malignancy, namely: What are the mechanisms that underlie disease progression from a relatively benign or chronic phase? By what therapeutic methods might one target residual leukemia stem cells in CML? Is JAK2(V617F) the original molecular event in MPD? What epigenetic events must have a role in dictating disease phenotype in MPDs? And finally, Will the benefits conferred by current or future JAK2(V617F) inhibitors equal or even surpass the clinical success that has resulted from the use of tyrosine kinase inhibitors in CML? These and others questions must be addressed and in some cases should be answered in the foreseeable future.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Hematology (Skoda)
UniBasel Contributors:Skoda, Radek C.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:0887-6924
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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