Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer

Schuller, Jan M. and Birrell, James A. and Tanaka, Hideaki and Konuma, Tsuyoshi and Wulfhorst, Hannes and Cox, Nicholas and Schuller, Sandra K. and Thiemann, Jacqueline and Lubitz, Wolfgang and Sétif, Pierre and Ikegami, Takahisa and Engel, Benjamin D. and Kurisu, Genji and Nowaczyk, Marc M.. (2019) Structural adaptations of photosynthetic complex I enable ferredoxin-dependent electron transfer. Science, 363 (6424). pp. 257-260.

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Official URL: https://edoc.unibas.ch/89553/

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Photosynthetic complex I enables cyclic electron flow around photosystem I, a regulatory mechanism for photosynthetic energy conversion. We report a 3.3-angstrom-resolution cryo-electron microscopy structure of photosynthetic complex I from the cyanobacterium Thermosynechococcus elongatus. The model reveals structural adaptations that facilitate binding and electron transfer from the photosynthetic electron carrier ferredoxin. By mimicking cyclic electron flow with isolated components in vitro, we demonstrate that ferredoxin directly mediates electron transfer between photosystem I and complex I, instead of using intermediates such as NADPH (the reduced form of nicotinamide adenine dinucleotide phosphate). A large rate constant for association of ferredoxin to complex I indicates efficient recognition, with the protein subunit NdhS being the key component in this process.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology and Biophysics (Engel)
UniBasel Contributors:Engel, Ben
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Sep 2022 10:21
Deposited On:23 Aug 2022 10:16

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