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Peptide-Assisted Nucleic Acid Delivery Systems on the Rise

Tarvirdipour, Shabnam and Skowicki, Michal and Schoenenberger, Cora-Ann and Palivan, Cornelia G.. (2021) Peptide-Assisted Nucleic Acid Delivery Systems on the Rise. International Journal of Molecular Sciences, 22 (16). p. 9092.

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Abstract

Concerns associated with nanocarriersâEurotm therapeutic efficacy and side effects have led to the development of strategies to advance them into targeted and responsive delivery systems. Owing to their bioactivity and biocompatibility, peptides play a key role in these strategies and, thus, have been extensively studied in nanomedicine. Peptide-based nanocarriers, in particular, have burgeoned with advances in purely peptidic structures and in combinations of peptides, both native and modified, with polymers, lipids, and inorganic nanoparticles. In this review, we summarize advances on peptides promoting gene delivery systems. The efficacy of nucleic acid therapies largely depends on cell internalization and the delivery to subcellular organelles. Hence, the review focuses on nanocarriers where peptides are pivotal in ferrying nucleic acids to their site of action, with a special emphasis on peptides that assist anionic, water-soluble nucleic acids in crossing the membrane barriers they encounter on their way to efficient function. In a second part, we address how peptides advance nanoassembly delivery tools, such that they navigate delivery barriers and release their nucleic acid cargo at specific sites in a controlled fashion.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Tarvirdipour, Shabnam and Skowicki, Michal Jerzy and Schönenberger, Cora-Ann
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
ISSN:1661-6596
e-ISSN:1422-0067
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
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Last Modified:17 May 2022 13:58
Deposited On:12 Dec 2021 17:28

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