Single-Cell Transcriptional Dynamics of Cell Fate Decisions during Chicken Development

Feregrino, Christian. Single-Cell Transcriptional Dynamics of Cell Fate Decisions during Chicken Development. 2021, Doctoral Thesis, University of Basel, Faculty of Science.


Official URL: https://edoc.unibas.ch/84458/

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In this thesis, I present a set of methods optimizations developed to study the development of the chicken embryo at single-cell resolution. I present also the study of cell fate decisions and patterning events at different scales, and from different perspectives. We produced a transcriptomic atlas of the different cell populations implicated in the patterning of the limb, made an in silico reconstruction of the cellfate decisions occurring during digit formation, explored the cell fate convergence driving skeletogenesis in different embryonic regions with different origins, and finally stablished a workflow for cross-species comparisons of co-expression signatures along developmental trajectories.
Advisors:Tschopp, Patrick and Salzburger, Walter and Payne, Joshua
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Regulatory Evolution (Tschopp)
UniBasel Contributors:Tschopp, Patrick and Salzburger, Walter
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14400
Thesis status:Complete
Number of Pages:159
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss144002
edoc DOI:
Last Modified:22 Oct 2021 04:30
Deposited On:21 Oct 2021 09:15

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