Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level

Lin, Qian and Manley, Jason and Helmreich, Magdalena and Schlumm, Friederike and Li, Jennifer M. and Robson, Drew N. and Engert, Florian and Schier, Alexander and Nöbauer, Tobias and Vaziri, Alipasha. (2020) Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level. Cell, 180 (3). pp. 536-551.e17.

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Official URL: https://edoc.unibas.ch/81817/

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Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Mar 2021 08:40
Deposited On:29 Mar 2021 08:40

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