Stat3 Controls Cell Movements during Zebrafish Gastrulation

Yamashita, Susumu and Miyagi, Chiemi and Carmany-Rampey, Amanda and Shimizu, Takashi and Fujii, Ritsuko and Schier, Alexander F. and Hirano, Toshio. (2002) Stat3 Controls Cell Movements during Zebrafish Gastrulation. Developmental Cell, 2 (3). pp. 363-375.

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Vertebrate axis formation requires both the correct specification of cell fates and the coordination of gastrulation movements. We report that the zebrafish signal transducer and activator of transcription 3 (Stat3) is activated on the dorsal side by the maternal Wnt/beta-catenin pathway. Zebrafish embryos lacking Stat3 activity display abnormal cell movements during gastrulation, resulting in a mispositioned head and a shortened anterior-posterior axis, but show no defects in early cell fate specification. Time course analysis, cell tracing, and transplantation experiments revealed that Stat3 activity is required cell autonomously for the anterior migration of dorsal mesendodermal cells and non-cell autonomously for the convergence of neighboring paraxial cells. These results reveal a role for Stat3 in controlling cell movements during gastrulation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Nov 2020 12:35
Deposited On:06 Nov 2020 12:35

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