EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1

Cheng, Simon K. and Olale, Felix and Bennett, James T. and Brivanlou, Ali H. and Schier, Alexander F.. (2003) EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. Genes and Development, 17 (1). pp. 31-36.

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Official URL: https://edoc.unibas.ch/74886/

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The TGF-beta signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cold Spring Harbor Laboratory Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Nov 2020 12:54
Deposited On:06 Nov 2020 12:54

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