Cheng, Simon K. and Olale, Felix and Bennett, James T. and Brivanlou, Ali H. and Schier, Alexander F.. (2003) EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1. Genes and Development, 17 (1). pp. 31-36.
Full text not available from this repository.
Official URL: https://edoc.unibas.ch/74886/
Downloads: Statistics Overview
Abstract
The TGF-beta signals Nodal, Activin, GDF1, and Vg1 have been implicated in mesoderm induction and left-right patterning. Nodal and Activin both activate Activin receptors, but only Nodal requires EGF-CFC coreceptors for signaling. We report that Vg1 and GDF1 signaling in zebrafish also depends on EGF-CFC proteins, but not on Nodal signals. Correspondingly, we find that in Xenopus Vg1 and GDF1 bind to and signal through Activin receptors only in the presence of EGF-CFC proteins. These results establish that multiple TGF-beta signals converge on Activin receptor/EGF-CFC complexes and suggest a more widespread requirement for coreceptors in TGF-beta signaling than anticipated previously.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier) |
|---|---|
| UniBasel Contributors: | Schier, Alexander F |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Cold Spring Harbor Laboratory Press |
| ISSN: | 0890-9369 |
| e-ISSN: | 1549-5477 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 06 Nov 2020 12:54 |
| Deposited On: | 06 Nov 2020 12:54 |
Repository Staff Only: item control page