Members of the miRNA-200 family regulate olfactory neurogenesis

Choi, Philip S. and Zakhary, Lisa and Choi, Wen-Yee and Caron, Sophie and Alvarez-Saavedra, Ezequiel and Miska, Eric A. and McManus, Mike and Harfe, Brian and Giraldez, Antonio J. and Horvitz, H. Robert and Schier, Alexander F. and Dulac, Catherine. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron, 57 (1). pp. 41-55.

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Official URL: https://edoc.unibas.ch/74735/

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MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Nov 2021 16:29
Deposited On:23 Nov 2021 16:29

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