Schier, Alexander F.. (2009) Nodal morphogens. Cold Spring Harbor Perspectives in Biology, 1 (5). a003459.
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Official URL: https://edoc.unibas.ch/74726/
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Abstract
Nodal signals belong to the TGF-beta superfamily and are essential for the induction of mesoderm and endoderm and the determination of the left-right axis. Nodal signals can act as morphogens-they have concentration-dependent effects and can act at a distance from their source of production. Nodal and its feedback inhibitor Lefty form an activator/inhibitor pair that behaves similarly to postulated reaction-diffusion models of tissue patterning. Nodal morphogen activity is also regulated by microRNAs, convertases, TGF-beta signals, coreceptors, and trafficking factors. This article describes how Nodal morphogens pattern embryonic fields and discusses how Nodal morphogen signaling is modulated.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier) |
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| UniBasel Contributors: | Schier, Alexander F |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Cold Spring Harbor Laboratory Press |
| e-ISSN: | 1943-0264 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 23 Nov 2021 16:23 |
| Deposited On: | 23 Nov 2021 16:23 |
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