Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

Rihel, Jason and Prober, David A. and Arvanites, Anthony and Lam, Kelvin and Zimmerman, Steven and Jang, Sumin and Haggarty, Stephen J. and Kokel, David and Rubin, Lee L. and Peterson, Randall T. and Schier, Alexander F.. (2010) Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science, 327 (5963). pp. 348-351.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/74725/

Downloads: Statistics Overview


A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors. Behavioral profiling revealed conserved functions of psychotropic molecules and predicted the mechanisms of action of poorly characterized compounds. In addition, behavioral profiling implicated new factors such as ether-a-go-go-related gene (ERG) potassium channels and immunomodulators in the control of rest and locomotor activity. These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:23 Nov 2021 16:22
Deposited On:23 Nov 2021 16:22

Repository Staff Only: item control page