Specified neural progenitors sort to form sharp domains after noisy Shh signaling

Xiong, Fengzhu and Tentner, Andrea R. and Huang, Peng and Gelas, Arnaud and Mosaliganti, Kishore R. and Souhait, Lydie and Rannou, Nicolas and Swinburne, Ian A. and Obholzer, Nikolaus D. and Cowgill, Paul D. and Schier, Alexander F. and Megason, Sean G.. (2013) Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell, 153 (3). pp. 550-561.

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Official URL: https://edoc.unibas.ch/74698/

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Sharply delineated domains of cell types arise in developing tissues under instruction of inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. The translation of a morphogen gradient into discrete spatial domains relies on precise signal responses at stable cell positions. However, cells in developing tissues undergoing morphogenesis and proliferation often experience complex movements, which may affect their morphogen exposure, specification, and positioning. How is a clear pattern achieved with cells moving around? Using in toto imaging of the zebrafish neural tube, we analyzed specification patterns and movement trajectories of neural progenitors. We found that specified progenitors of different fates are spatially mixed following heterogeneous Sonic Hedgehog signaling responses. Cell sorting then rearranges them into sharply bordered domains. Ectopically induced motor neuron progenitors also robustly sort to correct locations. Our results reveal that cell sorting acts to correct imprecision of spatial patterning by noisy inductive signals.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Nov 2021 16:38
Deposited On:22 Nov 2021 16:38

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