Toddler: an embryonic signal that promotes cell movement via Apelin receptors

Pauli, Andrea and Norris, Megan L. and Valen, Eivind and Chew, Guo-Liang and Gagnon, James A. and Zimmerman, Steven and Mitchell, Andrew and Ma, Jiao and Dubrulle, Julien and Reyon, Deepak and Tsai, Shengdar Q. and Joung, J. Keith and Saghatelian, Alan and Schier, Alexander F.. (2014) Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science, 343 (6172). p. 1248636.

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Official URL: https://edoc.unibas.ch/74692/

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It has been assumed that most, if not all, signals regulating early development have been identified. Contrary to this expectation, we identified 28 candidate signaling proteins expressed during zebrafish embryogenesis, including Toddler, a short, conserved, and secreted peptide. Both absence and overproduction of Toddler reduce the movement of mesendodermal cells during zebrafish gastrulation. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. Toddler drives internalization of G protein-coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander F
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Dec 2020 17:02
Deposited On:16 Dec 2020 17:02

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