Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets

Wee, Caroline L. and Nikitchenko, Maxim and Wang, Wei-Chun and Luks-Morgan, Sasha J. and Song, Erin and Gagnon, James A. and Randlett, Owen and Bianco, Isaac H. and Lacoste, Alix M. B. and Glushenkova, Elena and Barrios, Joshua P. and Schier, Alexander F. and Kunes, Samuel and Engert, Florian and Douglass, Adam D.. (2019) Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Nature neuroscience, 22 (9). pp. 1477-1492.

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Official URL: https://edoc.unibas.ch/73208/

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Animals have evolved specialized neural circuits to defend themselves from pain- and injury-causing stimuli. Using a combination of optical, behavioral and genetic approaches in the larval zebrafish, we describe a novel role for hypothalamic oxytocin (OXT) neurons in the processing of noxious stimuli. In vivo imaging revealed that a large and distributed fraction of zebrafish OXT neurons respond strongly to noxious inputs, including the activation of damage-sensing TRPA1 receptors. OXT population activity reflects the sensorimotor transformation of the noxious stimulus, with some neurons encoding sensory information and others correlating more strongly with large-angle swims. Notably, OXT neuron activation is sufficient to generate this defensive behavior via the recruitment of brainstem premotor targets, whereas ablation of OXT neurons or loss of the peptide attenuates behavioral responses to TRPA1 activation. These data highlight a crucial role for OXT neurons in the generation of appropriate defensive responses to noxious input.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Schier)
UniBasel Contributors:Schier, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2020 13:20
Deposited On:31 Aug 2020 13:20

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