Stader, Felix and Penny, Melissa A. and Siccardi, Marco and Marzolini, Catia. (2019) A comprehensive framework for physiologically based pharmacokinetic modelling in Matlab. CPT: Pharmacometrics and Systems Pharmacology, 8 (7). pp. 444-459.
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Abstract
Physiologically based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole-body PBPK model in Matlab; ®; to answer specific pharmacological questions involving drug disposition, and magnitudes of drug-drug interactions in different patient populations.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Disease Modelling > Disease Modelling and Intervention Dynamics (Penny) |
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| UniBasel Contributors: | Marzolini, Catia and Stader, Felix and Penny, Melissa |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| e-ISSN: | 2163-8306 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 07 Jul 2023 15:38 |
| Deposited On: | 25 Feb 2019 14:20 |
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