The role of nucleocytoplasmic transport in mechanotransduction

Kassianidou, Elena and Kalita, Joanna and Lim, Roderick Y. H.. (2019) The role of nucleocytoplasmic transport in mechanotransduction. Experimental cell research, 377 (1-2). pp. 86-93.

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Official URL: https://edoc.unibas.ch/69616/

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Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time. This is vital for cell migration and proliferation as well as tissue morphogenesis and remodeling. While the force-sensing and force-transducing mechanisms are generally known, it remains unclear how mechanoresponsive transcription factors (TFs) are selectively translocated into the nucleus upon force activation. Such TFs include Yes-Associated Protein (YAP), Myocardin Related Transcription Factor (MRTF), Hypoxia Induced Factors (HIF) and others. Here, we discuss how the nucleocytoplasmic transport machinery intersects with mechanoresponsive TFs to facilitate their selective transport through nuclear pore complexes.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim)
UniBasel Contributors:Lim, Roderick Y.H. and Kassianidou, Elena and Kalita, Joanna Malgorzata
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Aug 2020 12:53
Deposited On:07 Aug 2020 12:53

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