Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy

Koelzer, Viktor H. and Buser, Tobias and Willi, Niels and Rothschild, Sacha I. and Wicki, Andreas and Schiller, Peter and Cathomas, Gieri and Zippelius, Alfred and Mertz, Kirsten D.. (2016) Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. Journal for ImmunoTherapy of Cancer, 4. p. 47.

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Official URL: https://edoc.unibas.ch/62545/

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BACKGROUND: Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (PD-L1). Skin toxicity most commonly includes a maculopapular erythematous rash and pruritus. Rarely life threatening complications such as Steven's Johnson syndrome or toxic epidermal necrolysis may occur. CASE PRESENTATION: Here we report the uncommon event of a drug-induced transient acantholytic dermatosis (Grover's disease) in a 73-year-old Caucasian male treated with ipilimumab for metastatic melanoma. Five weeks after initiation of therapy, the patient developed a widespread polymorphic papulovesicular dermatosis on the trunk and proximal extremities with intense pruritus. Skin biopsy showed acantholytic dyskeratosis with interface dermatitis consistent with a Grover's-like drug eruption. CONCLUSIONS: These findings should raise awareness for uncommon immune-related dermatological toxicities of immunomodulatory antibodies targeting the CTLA-4 signaling axis. We recommend biopsies of unexpected skin lesions to rapidly identify dermatological adverse events of immune checkpoint inhibitors.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cancer Immunology and Biology (Zippelius/Rochlitz)
UniBasel Contributors:Zippelius, Alfred
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2051-1426 (Print) 2051-1426 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Dec 2018 11:53
Deposited On:22 Dec 2018 11:53

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