Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications

Pollack, Rena M. and Donath, Marc Y. and LeRoith, Derek and Leibowitz, Gil. (2016) Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications. Diabetes Care, 39 Suppl 2. pp. 244-252.

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The association between hyperglycemia and inflammation and vascular complications in diabetes is now well established. Antidiabetes drugs may alleviate inflammation by reducing hyperglycemia; however, the anti-inflammatory effects of these medications are inconsistent and it is unknown whether their beneficial metabolic effects are mediated via modulation of chronic inflammation. Recent data suggest that immunomodulatory treatments may have beneficial effects on glycemia, beta-cell function, and insulin resistance. However, the mechanisms underlying their beneficial metabolic effects are not always clear, and there are concerns regarding the specificity, safety, and efficacy of immune-based therapies. Herein, we review the anti-inflammatory and metabolic effects of current antidiabetes drugs and of anti-inflammatory therapies that were studied in patients with type 2 diabetes. We discuss the potential benefit of using anti-inflammatory treatments in diabetes and important issues that should be addressed prior to implementation of such therapeutic approaches.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Diabetes Research (Donath)
UniBasel Contributors:Donath, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Diabetes Association
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Jul 2020 14:52
Deposited On:21 Jul 2020 14:52

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