Finlayson, R. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Bourguet-Kondracki, M. L. and Harper, J. L. and Webb, V. L. and Copp, B. R.. (2011) Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. Journal of Natural Products, 74 (4). pp. 888-892.
Full text not available from this repository.
Official URL: http://edoc.unibas.ch/47144/
Downloads: Statistics Overview
Abstract
Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N(1) position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC(50)'s of 15 and 8.4 muM, respectively
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
|---|---|
| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 0163-3864 |
| e-ISSN: | 1520-6025 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Related URLs: | |
| Identification Number: |
|
| Last Modified: | 23 Mar 2017 15:07 |
| Deposited On: | 23 Mar 2017 15:07 |
Repository Staff Only: item control page