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Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp

Finlayson, R. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Bourguet-Kondracki, M. L. and Harper, J. L. and Webb, V. L. and Copp, B. R.. (2011) Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. Journal of Natural Products, 74 (4). pp. 888-892.

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Official URL: http://edoc.unibas.ch/47144/

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Abstract

Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of 2D NMR spectra and confirmed via synthesis, embody an indole-3-glyoxylamide moiety linked to the N(1) position of spermidine, the latter motif being particularly rare among marine natural products. Didemnidine B and a synthetic precursor exhibited mild in vitro growth inhibition of Plasmodium falciparum with IC(50)'s of 15 and 8.4 muM, respectively
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Publisher:American Chemical Society
ISSN:0163-3864
e-ISSN:1520-6025
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Mar 2017 15:07
Deposited On:23 Mar 2017 15:07

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