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Towards reconciling structure and function in the nuclear pore complex

Lim, Roderick Y. H. and Aebi, Ueli and Fahrenkrog, Birthe. (2008) Towards reconciling structure and function in the nuclear pore complex. Histochemistry and cell biology, 129 (2). pp. 105-116.

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Official URL: http://edoc.unibas.ch/dok/A5259595

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Abstract

The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope. Being the only passageway in and out of the nucleus, the nuclear pore complex (NPC) has the principal function of regulating the high throughput of nucleocytoplasmic transport in a highly selective manner so as to maintain cellular order and function. Here, we present a retrospective review of the evidence that has led to the current understanding of both NPC structure and function. Looking towards the future, we contemplate on how various outstanding effects and nanoscopic characteristics ought to be addressed, with the goal of reconciling structure and function into a single unified picture of the NPC.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Aebi)
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Fahrenkrog)
05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim)
UniBasel Contributors:Lim, Roderick Y.H. and Aebi, Ueli and Fahrenkrog, Birthe
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer International
ISSN:0301-5564
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:10 Apr 2018 14:52
Deposited On:22 Mar 2012 13:23

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