Skoda, R. C. and Schwaller, J.. (2011) HiJAKing the methylosome in myeloproliferative disorders. Cancer cell, Vol. 19, H. 2. pp. 161-163.
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Official URL: http://edoc.unibas.ch/dok/A6004065
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Abstract
JAK2 gain-of-function mutations have been shown to cause myeloproliferative neoplasms. In this issue of Cancer Cell, Liu et al. (2011) demonstrate that these JAK2 mutants, but not wild-type JAK2, directly phosphorylate PRMT5 and inhibit its arginine methyltransferase activity, establishing a link between mutant JAK2 and histone arginine methylation.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Childhood Leukemia (Schwaller) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Experimental Hematology (Skoda) 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Molekulare Medizin (Skoda) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Molekulare Medizin (Skoda) |
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| UniBasel Contributors: | Schwaller, Jürg and Skoda, Radek C. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Cell Press |
| ISSN: | 1535-6108 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Identification Number: |
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| Last Modified: | 08 May 2015 08:45 |
| Deposited On: | 27 Feb 2014 15:45 |
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