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2017

Dafflon, Caroline and Craig, Vanessa J. and Méreau, Hélène and Gräsel, Julius and Schacher Engstler, Barbara and Hoffman, Gregory R. and Nigsch, Florian and Gaulis, Swann and Barys, Louise and Ito, Moriko and Aguadé-Gorgorió, Julia and Bornhauser, Beat and Bourquin, Jean-Pierre and Proske, Amelie and Stork-Fux, Caroline and Murakami, Masato and Sellers, William and Hofmann, Francesco and Schwaller, Jürg and Tiedt, Ralph. (2017) Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Leukemia, 31 (6). pp. 1269-1277.

2016

Picaud, Sarah and Leonards, Katharina and Lambert, Jean-Philippe and Dovey, Oliver and Wells, Christopher and Fedorov, Oleg and Monteiro, Octovia and Fujisawa, Takao and Wang, Chen-Yi and Lingard, Hannah and Tallant, Cynthia and Nikbin, Nikzad and Guetzoyan, Lucie and Ingham, Richard and Ley, Steven V. and Brennan, Paul and Muller, Susanne and Samsonova, Anastasia and Gingras, Anne-Claude and Schwaller, Juerg and Vassiliou, George and Knapp, Stefan and Filippakopoulos, Panagis. (2016) Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Science advances, 2 (10). e1600760.

Stavropoulou, Vaia and Kaspar, Susanne and Brault, Laurent and Sanders, Mathijs A. and Juge, Sabine and Morettini, Stefano and Tzankov, Alexandar and Iacovino, Michelina and Lau, I-Jun and Milne, Thomas A. and Royo, Hélène and Kyba, Michael and Valk, Peter J. M. and Peters, Antoine H. F. M. and Schwaller, Juerg. (2016) MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome. Cancer cell, 30 (1). pp. 43-58.

Fahrenkrog, Birthe and Martinelli, Valérie and Nilles, Nadine and Fruhmann, Gernot and Chatel, Guillaume and Juge, Sabine and Sauder, Ursula and Di Giacomo, Danika and Mecucci, Cristina and Schwaller, Jürg. (2016) Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype. PloS one, 11 (3). e0152321.

2015

Qiu, Jihui J. and Zeisig, Bernd B. and Li, S. and Liu, W. and Chu, H. and Song, Y. and Giordano, A. and Schwaller, Jürg and Gronemeyer, H. and Dong, S. and So, C. W. E.. (2015) Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia. Leukemia, 29 (5). pp. 1153-1162.

Picaud, Sarah and Fedorov, Oleg and Thanasopoulou, Angeliki and Leonards, Katharina and Jones, Katherine and Meier, Julia and Olzscha, Heidi and Monteiro, Octovia and Martin, Sarah and Philpott, Martin and Tumber, Anthony and Filippakopoulos, Panagis and Yapp, Clarence and Wells, Christopher and Che, Ka Hing and Bannister, Andrew and Robson, Samuel and Kumar, Umesh and Parr, Nigel and Lee, Kevin and Lugo, Dave and Jeffrey, Philip and Taylor, Simon and Vecellio, Matteo L. and Bountra, Chas and Brennan, Paul E. and O'Mahony, Alison and Velichko, Sharlene and Müller, Susanne and Hay, Duncan and Daniels, Danette L. and Urh, Marjeta and La Thangue, Nicholas B. and Kouzarides, Tony and Prinjha, Rab and Schwaller, Jürg and Knapp, Stefan. (2015) Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer research, 75 (23). pp. 5106-5119.

2014

Sánchez-Aguilera, Abel and Arranz, Lorena and Martín-Pérez, Daniel and García-García, Andrés and Stavropoulou, Vaia and Kubovcakova, Lucia and Isern, Joan and Martín-Salamanca, Sandra and Langa, Xavier and Skoda, Radek C. and Schwaller, Jürg and Méndez-Ferrer, Simón. (2014) Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell, 15 (6). pp. 791-804.

Cermáková, Kateřina and Tesina, Petr and Demeulemeester, Jonas and El Ashkar, Sara and Méreau, Hélène and Schwaller, Juerg and Rezáčová, Pavlína and Veverka, Vaclav and De Rijck, Jan. (2014) Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia. Cancer Research, 74 (18). pp. 5139-5151.

Arranz, Lorena and Sánchez-Aguilera, Abel and Martín-Pérez, Daniel and Isern, Joan and Langa, Xavier and Tzankov, Alexandar and Lundberg, Pontus and Muntión, Sandra and Tzeng, Yi-Shiuan and Lai, Dar-Ming and Schwaller, Jürg and Skoda, Radek C. and Méndez-Ferrer, Simón. (2014) Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature, 512 (7512). pp. 78-81.

Thanasopoulou, Angeliki and Tzankov, Alexandar and Schwaller, Juerg. (2014) Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction. Haematologica, 99 (9). pp. 1465-1471.

Decker, Sarah and Finter, Johannes and Forde, Aaron James and Kissel, Sandra and Schwaller, Juerg and Mack, Thomas Sebastian and Kuhn, Anabel and Gray, Nathanael and Follo, Marie and Jumaa, Hassan and Burger, Meike and Zirlik, Katja and Pfeifer, Dietmar and Miduturu, Chandrasekhar V. and Eibel, Hermann and Veelken, Hendrik and Dierks, Christine. (2014) PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1). Molecular Cancer Therapeutics, 13 (5). pp. 1231-1245.

Brault, L. and Rovó, A. and Decker, S. and Dierks, C. and Tzankov, A. and Schwaller, J.. (2014) CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia. Leukemia, 28 (3). pp. 566-576.

2013

Méreau, Helene and Schwaller, Juerg. (2013) Trithorax and polycomb cooperation in MLL fusion acute leukemia. Haematologica, 98 (6). pp. 825-827.

Picaud, Sarah and Da Costa, David and Thanasopoulou, Angeliki and Filippakopoulos, Panagis and Fish, Paul V. and Philpott, Martin and Fedorov, Oleg and Brennan, Paul and Bunnage, Mark E. and Owen, Dafydd R. and Bradner, James E. and Taniere, Philippe and O'Sullivan, Brendan and Müller, Susanne and Schwaller, Juerg and Stankovic, Tatjana and Knapp, Stefan. (2013) PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Research, 73 (11). pp. 3336-3346.

Méreau, Hélène and De Rijck, Jan and Cermáková, Kateřina and Kutz, Alexander and Juge, Sabine and Demeulemeester, Jonas and Gijsbers, Rik and Christ, Frauke and Debyser, Zeger and Schwaller, Jürg. (2013) Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75). Leukemia, 27 (6). pp. 1245-1253.

2012

Schwaller, Jurg. (2012) Modeling ETV6-JAK2-induced leukemia: insights from the zebrafish. Haematologica, 97 (12). pp. 1783-1785.

Walpen, Thomas and Peier, Martin and Haas, Elvira and Kalus, Ina and Schwaller, Jürg and Battegay, Edouard and Humar, Rok. (2012) Loss of pim1 imposes a hyperadhesive phenotype on endothelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30 (4). pp. 1083-1096.

Walpen, Thomas and Kalus, Ina and Schwaller, Jürg and Peier, Martin A. and Battegay, Edouard J. and Humar, Rok. (2012) Nuclear PIM1 confers resistance to rapamycin-impaired endothelial proliferation. Biochemical and Biophysical Research Communications, 429 (1-2). pp. 24-30.

Brault, Laurent and Menter, Thomas and Obermann, Ellen C. and Knapp, Stefan and Thommen, Sarah and Schwaller, Jürg and Tzankov, Alexandar. (2012) PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. British journal of cancer, 107 (3). pp. 491-500.

Thanasopoulou, Angeliki and Stravopodis, Dimitrios J. and Dimas, Konstantinos S. and Schwaller, Juerg and Anastasiadou, Ema. (2012) Loss of CCDC6 affects cell cycle through impaired intra-S-phase checkpoint control. PLoS ONE, 7 (2). e31007.

Huber, Kilian and Brault, Laurent and Fedorov, Oleg and Gasser, Christelle and Filippakopoulos, Panagis and Bullock, Alex N. and Fabbro, Doriano and Trappe, Jörg and Schwaller, Jürg and Knapp, Stefan and Bracher, Franz. (2012) 7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. Journal of Medicinal Chemistry, 55 (1). pp. 403-413.

2011

Peters, Antoine H. F. M. and Schwaller, Juerg. (2011) Epigenetic mechanisms in acute myeloid leukemia. Progress in drug research, Vol. 67. pp. 197-219.

Miduturu, Chandrasekhar V. and Deng, Xianming and Kwiatkowski, Nicholas and Yang, Wannian and Brault, Laurent and Filippakopoulos, Panagis and Chung, Eunah and Yang, Qingkai and Schwaller, Juerg and Knapp, Stefan and King, Randall W. and Lee, Jiing-Dwan and Herrgard, Sanna and Zarrinkar, Patrick and Gray, Nathanael S.. (2011) High-throughput kinase profiling : a more efficient approach toward the discovery of new kinase inhibitors. Chemistry & biology, Vol. 18, H. 7. pp. 868-879.

Skoda, R. C. and Schwaller, J.. (2011) HiJAKing the methylosome in myeloproliferative disorders. Cancer cell, Vol. 19, H. 2. pp. 161-163.

2010

Liu, T. and Jankovic, D. and Brault, L. and Ehret, S. and Baty, F. and Stavropoulou, V. and Rossi, V. and Biondi, A. and Schwaller, J.. (2010) Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. Leukemia, Vol. 24, no. 3. pp. 601-612.

Brault, Laurent and Gasser, Christelle and Bracher, Franz and Huber, Kilian and Knapp, Stefan and Schwaller, Jürg. (2010) PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica, Vol. 95, H. 6. pp. 1004-1015.

Stavropoulou, Vaia and Brault, Laurent and Schwaller, Juerg. (2010) Insights into molecular pathways for targeted therapeutics in acute leukemia. Swiss medical weekly, Vol. 140 , w13068.

2009

Meier, Cecile and Hoeller, Sylvia and Bourgau, Caroline and Hirschmann, Petra and Schwaller, Juerg and Went, Philip and Pileri, Stefano A. and Reiter, Andreas and Dirnhofer, Stephan and Tzankov, Alexandar. (2009) Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Vol. 22. pp. 476-487.

Mumprecht, Sabine and Schürch, Christian and Schwaller, Juerg and Solenthaler, Max and Ochsenbein, Adrian F.. (2009) Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression. Blood : the journal of the American Society of Hematology, Vol. 114. pp. 1528-1536.

Grundler, Rebekka and Brault, Laurent and Gasser, Christelle and Bullock, Alex N. and Dechow, Tobias and Woetzel, Sabine and Pogacic, Vanda and Villa, Antonello and Ehret, Sabine and Berridge, Georgina and Spoo, Anke and Dierks, Christine and Biondi, Andrea and Knapp, Stefan and Duyster, Justus and Schwaller, Juerg. (2009) Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. Journal of experimental medicine, 206 (9). pp. 1957-1970.

Grundler, Rebekka and Brault, Laurent and Gasser, Christelle and Bullock, Alex N. and Dechow, Tobias and Woetzel, Sabine and Pogacic, Vanda and Villa, Antonello and Ehret, Sabine and Berridge, Georgina and Spoo, Anke and Dierks, Christine and Biondi, Andrea and Knapp, Stefan and Duyster, Justus and Schwaller, Juerg. (2009) Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. Journal of Experimental Medicine, 206 (9). pp. 1957-1970.

2008

Mhawech-Fauceglia, P. and Smiraglia, D. J. and Bshara, W. and Andrews, C. and Schwaller, J. and South, S. and Higgs, D. and Lele, S. and Herrmann, F. and Odunsi, K.. (2008) Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma. Cancer epidemiology biomarkers & prevention, Vol. 17, H. 3. pp. 571-577.

Went, P. and Tzankov, A. and Schwaller, J. and Passweg, J. and Roosnek, E. and Huard, B.. (2008) Role of the tumor necrosis factor ligand APRIL in Hodgkin's lymphoma : a retrospective study including 107 cases. Experimental hematology, Vol. 36, H. 5. pp. 533-534.

Jankovic, Dragana and Gorello, Paolo and Liu, Ting and Ehret, Sabine and La Starza, Robert and Desjobert, Cecile and Baty, Florent and Brutsche, Martin H. and Jayaraman, Padma-Sheila and Santoro, Alessandra and Mecucci, Christina and Schwaller, Juerg. (2008) Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia. Blood, 111 (12). pp. 5672-5682.

Tiedt, Ralph and Hao-Shen, Hui and Sobas, Marta A. and Looser, Renate and Dirnhofer, Stephan and Schwaller, Jürg and Skoda, Radek C.. (2008) Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood, 111 (8). pp. 3931-3940.