Items where Author is "Hemkens, Lars G."

2022

Schwab, Simon and Janiaud, Perrine and Dayan, Michael and Amrhein, Valentin and Panczak, Radoslaw and Palagi, Patricia M. and Hemkens, Lars G. and Ramon, Meike and Rothen, Nicolas and Senn, Stephen and Furrer, Eva and Held, Leonhard. (2022) Ten simple rules for good research practice. PLoS Computational Biology, 18 (6). e1010139.

2021

Herbrand, Amanda Katherina and Schmitt, Andreas M. and Briel, Matthias and Ewald, Hannah and Goldkuhle, Marius and Diem, Stefan and Hoogkamer, Anouk and Joerger, Markus and Moffa, Giusi and Novak, Urban and Hemkens, Lars G. and Kasenda, Benjamin. (2021) Association of Supporting Trial Evidence and Reimbursement for Off-Label Use of Cancer Drugs. Jama Network Open, 4 (3). e210380.

Lohner, Szimonetta and Gryaznov, Dmitry and von Niederhäusern, Belinda and Speich, Benjamin and Kasenda, Benjamin and Ojeda-Ruiz, Elena and Schandelmaier, Stefan and Mertz, Dominik and Odutayo, Ayodele and Tomonaga, Yuki and Amstutz, Alain and Pauli-Magnus, Christiane and Gloy, Viktoria and Bischoff, Karin and Wollmann, Katharina and Rehner, Laura and Meerpohl, Joerg J. and Nordmann, Alain and Klatte, Katharina and Ghosh, Nilabh and Heravi, Ala Taji and Wong, Jacqueline and Chow, Ngai and Hong, Patrick Jiho and McCord, Kimberly and Sricharoenchai, Sirintip and Busse, Jason W. and Agarwal, Arnav and Saccilotto, Ramon and Schwenkglenks, Matthias and Moffa, Giusi and Hemkens, Lars G. and Hopewell, Sally and von Elm, Erik and Blümle, Anette and Briel, Matthias. (2021) Reporting quality of trial protocols improved for non-regulated interventions but not regulated interventions: A repeated cross-sectional study. Journal of Clinical Epidemiology, 139. pp. 340-349.

Mc Cord, Kimberly A. and Ewald, Hannah and Agarwal, Arnav and Glinz, Dominik and Aghlmandi, Soheila and Ioannidis, John P. A. and Hemkens, Lars G.. (2021) Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study. BMJ, 372. n450.

2020

Speich, Benjamin and Gloy, Viktoria and Schur, Nadine and Ewald, Hannah and Hemkens, Lars G. and Schwenkglenks, Matthias and Briel, Matthias and MAking Randomized Trials Affordable Group, . (2020) A scoping review shows that several nonvalidated budget planning tools for randomized trials are available. Journal of Clinical Epidemiology, 117. pp. 9-19.

Ewald, Hannah and Klerings, Irma and Wagner, Gernot and Heise, Thomas L. and Dobrescu, Andreea Iulia and Armijo-Olivo, Susan and Stratil, Jan M. and Lhachimi, Stefan K. and Mittermayr, Tarquin and Gartlehner, Gerald and Nussbaumer-Streit, Barbara and Hemkens, Lars G.. (2020) Abbreviated and comprehensive literature searches led to identical or very similar effect estimates: meta-epidemiological study. Journal of Clinical Epidemiology, 128. pp. 1-12.

Schandelmaier, Stefan and Schmitt, Andreas M. and Herbrand, Amanda K. and Glinz, Dominik and Ewald, Hannah and Briel, Matthias and Guyatt, Gordon H. and Hemkens, Lars G. and Kasenda, Benjamin. (2020) Characteristics and interpretation of subgroup analyses based on tumour characteristics in randomised trials testing target-specific anticancer drugs: design of a systematic survey. BMJ open, 10 (5). e034565.

Ladanie, Aviv and Schmitt, Andreas M. and Speich, Benjamin and Naudet, Florian and Agarwal, Arnav and Pereira, Tiago V. and Sclafani, Francesco and Herbrand, Amanda K. and Briel, Matthias and Martin-Liberal, Juan and Schmid, Thomas and Ewald, Hannah and Ioannidis, John P. A. and Bucher, Heiner C. and Kasenda, Benjamin and Hemkens, Lars G.. (2020) Clinical trial evidence supporting US Food and Drug Administration approval of novel cancer therapies between 2000 and 2016. Jama Network Open, 3 (11). e2024406.

Kasenda, Benjamin and Liu, Junhao and Jiang, Yu and Gajewski, Byron and Wu, Cen and von Elm, Erik and Schandelmaier, Stefan and Moffa, Giusi and Trelle, Sven and Schmitt, Andreas Michael and Herbrand, Amanda K. and Gloy, Viktoria and Speich, Benjamin and Hopewell, Sally and Hemkens, Lars G. and Sluka, Constantin and McGill, Kris and Meade, Maureen and Cook, Deborah and Lamontagne, Francois and Tréluyer, Jean-Marc and Haidich, Anna-Bettina and Ioannidis, John P. A. and Treweek, Shaun and Briel, Matthias. (2020) Prediction of RECRUITment In Randomized Clinical Trials (RECRUIT-IT) - Rationale and Design for an International Collaborative Study. Trials, 21. p. 731.

Janiaud, Perrine and Axfors, Cathrine and Van't Hooft, Janneke and Saccilotto, Ramon and Agarwal, Arnav and Appenzeller-Herzog, Christian and Contopoulos-Ioannidis, Despina G. and Danchev, Valentin and Dirnagl, Ulrich and Ewald, Hannah and Gartlehner, Gerald and Goodman, Steven N. and Haber, Noah A. and Ioannidis, Angeliki Diotima and Ioannidis, John P. A. and Lythgoe, Mark P. and Ma, Wenyan and Macleod, Malcolm and Malički, Mario and Meerpohl, Joerg J. and Min, Yan and Moher, David and Nagavci, Blin and Naudet, Florian and Pauli-Magnus, Christiane and O'Sullivan, Jack W. and Riedel, Nico and Roth, Jan A. and Sauermann, Mandy and Schandelmaier, Stefan and Schmitt, Andreas M. and Speich, Benjamin and Williamson, Paula R. and Hemkens, Lars G.. (2020) The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days. F1000Research, 9. p. 1193.

2019

Herbrand, Amanda Katherina and Schmitt, Andreas Michael and Briel, Matthias and Diem, Stefan and Ewald, Hannah and Hoogkamer, Anouk and Joerger, Markus and Mc Cord, Kimberly Alba and Novak, Urban and Sricharoenchai, Sirintip and Hemkens, Lars G. and Kasenda, Benjamin. (2019) Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project. ESMO open, 4 (6). e000596.

Mc Cord, Kimberly A. and Ewald, Hannah and Ladanie, Aviv and Briel, Matthias and Speich, Benjamin and Bucher, Heiner C. and Hemkens, Lars G. and RCD for RCTs initiative and the Making Randomized Trials More Af, . (2019) Current use and costs of electronic health records for clinical trial research : a descriptive study. CMAJ open, 7 (1). E23-E32.

Ewald, Hannah and Speich, Benjamin and Ladanie, Aviv and Bucher, Heiner C. and Ioannidis, John P. A. and Hemkens, Lars G.. (2019) Marginal structural models and other analyses allow multiple estimates of treatment effects in randomized clinical trials: Meta-epidemiological analysis. Journal of clinical epidemiology, 107. pp. 12-26.

Ewald, Hannah and Ioannidis, John P. A. and Ladanie, Aviv and Mc Cord, Kimberly and Bucher, Heiner C. and Hemkens, Lars G.. (2019) Nonrandomized studies using causal-modeling may give different answers than RCTs: a meta-epidemiological study. Journal of clinical epidemiology, 118. pp. 29-41.

Speich, Benjamin and Schur, Nadine and Gryaznov, Dmitry and von Niederhäusern, Belinda and Hemkens, Lars G. and Schandelmaier, Stefan and Amstutz, Alain and Kasenda, Benjamin and Pauli-Magnus, Christiane and Ojeda-Ruiz, Elena and Tomonaga, Yuki and McCord, Kimberly and Nordmann, Alain and von Elm, Erik and Briel, Matthias and Schwenkglenks, Matthias and a collaboration of the Marta Aspire Study Groups, . (2019) Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation. PLoS ONE, 14 (1). e0210669.

Ladanie, Aviv and Speich, Benjamin and Briel, Matthias and Sclafani, Francesco and Bucher, Heiner C. and Agarwal, Arnav and Ioannidis, John P. A. and Pereira, Tiago V. and Kasenda, Benjamin and Hemkens, Lars G.. (2019) Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies. Journal of clinical epidemiology, 114. pp. 49-59.

Speich, Benjamin and Bausch, Kathrin and Roth, Jan A. and Hemkens, Lars G. and Ewald, Hannah and Vogt, Deborah R. and Bruni, Nicole and Deuster, Stefanie and Seifert, Hans-H. and Widmer, Andreas F.. (2019) Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo controlled non-inferiority trial (CITrUS trial). Trials, 20. p. 142.

2018

Ladanie, Aviv and Ewald, Hannah and Kasenda, Benjamin and Hemkens, Lars G.. (2018) How to use FDA drug approval documents for evidence syntheses. BMJ, 362. k2815.

Ladanie, Aviv and Ioannidis, John P. A. and Stafford, Randall S. and Ewald, Hannah and Bucher, Heiner C. and Hemkens, Lars G. and Hemkens, Lars G.. (2018) Off-label prescription : experience is a gloomy lantern that does not even illuminate its bearer. Journal of clinical epidemiology, 101. pp. 127-128.

Ladanie, Aviv and Ioannidis, John P. A. and Stafford, Randall S. and Ewald, Hannah and Bucher, Heiner C. and Hemkens, Lars G.. (2018) Off-label treatments were not consistently better or worse than approved drug treatments in randomized trials. Journal of clinical epidemiology, 94. pp. 35-45.

Speich, Benjamin and von Niederhäusern, Belinda and Blum, Claudine Angela and Keiser, Jennifer and Schur, Nadine and Fürst, Thomas and Kasenda, Benjamin and Christ-Crain, Mirjam and Hemkens, Lars G. and Pauli-Magnus, Christiane and Schwenkglenks, Matthias and Briel, Matthias and Making Randomized Trials Affordable Group, . (2018) Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list. Journal of clinical epidemiology, 96. pp. 73-83.

Speich, Benjamin and von Niederhäusern, Belinda and Schur, Nadine and Hemkens, Lars G. and Fürst, Thomas and Bhatnagar, Neera and Alturki, Reem and Agarwal, Arnav and Kasenda, Benjamin and Pauli-Magnus, Christiane and Schwenkglenks, Matthias and Briel, Matthias and Making Randomized Trials Affordable Group, . (2018) Systematic review on costs and resource use of randomized clinical trials shows a lack of transparent and comprehensive data. Journal of clinical epidemiology, 96. pp. 1-11.

Ladanie, Aviv and Speich, Benjamin and Naudet, Florian and Agarwal, Arnav and Pereira, Tiago V. and Sclafani, Francesco and Martin-Liberal, Juan and Schmid, Thomas and Ewald, Hannah and Ioannidis, John P. A. and Bucher, Heiner C. and Kasenda, Benjamin and Hemkens, Lars G.. (2018) The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: rationale and design of the database and the collection of evidence available at approval of novel drugs. Trials, 19 (1). p. 505.

Speich, Benjamin and Thomer, Anja and Aghlmandi, Soheila and Ewald, Hannah and Zeller, Andreas and Hemkens, Lars G.. (2018) Treatments for subacute cough in primary care : systematic review and meta-analyses of randomised clinical trials. The British journal of general practice, 68 (675). e694-e702.

January 2017

Hemkens, Lars G. and Ewald, Hannah and Naudet, Florian and Ladanie, Aviv and Shaw, Jonathan G. and Sajeev, Gautam and Ioannidis, John P. A.. (2017) Interpretation of epidemiologic studies very often lacked adequate consideration of confounding. Journal of Clinical Epidemiology, 93. pp. 94-102.

2017

Ewald, Hannah and Santini-Oliveira, Marilia and Bühler, Julian-Emanuel and Vuichard, Danielle and Schandelmaier, Stefan and Stöckle, Marcel and Briel, Matthias and Bucher, Heiner C. and Hemkens, Lars G.. (2017) Comparative effectiveness of tenofovir in HIV-infected treatment-experienced patients: systematic review and meta-analysis. HIV clinical trials, 18 (1). pp. 17-27.

Schandelmaier, Stefan and Tomonaga, Yuki and Bassler, Dirk and Meerpohl, Joerg J. and von Elm, Erik and You, John J. and Bluemle, Anette and Lamontagne, Francois and Saccilotto, Ramon and Amstutz, Alain and Bengough, Theresa and Stegert, Mihaela and Olu, Kelechi K. and Tikkinen, Kari A. O. and Neumann, Ignacio and Carrasco-Labra, Alonso and Faulhaber, Markus and Mulla, Sohail M. and Mertz, Dominik and Akl, Elie A. and Sun, Xin and Busse, Jason W. and Ferreira-González, Ignacio and Nordmann, Alain and Gloy, Viktoria and Raatz, Heike and Moja, Lorenzo and Rosenthal, Rachel and Ebrahim, Shanil and Vandvik, Per O. and Johnston, Bradley C. and Walter, Martin A. and Burnand, Bernard and Schwenkglenks, Matthias and Hemkens, Lars G. and Guyatt, Gordon and Bucher, Heiner C. and Kasenda, Benjamin and Briel, Matthias. (2017) Premature Discontinuation of Pediatric Randomized Controlled Trials: A Retrospective Cohort Study. The Journal of Pediatrics, 184. pp. 209-214.e1.

2016

Hemkens, Lars G. and Ewald, Hannah and Gloy, Viktoria L. and Arpagaus, Armon and Olu, Kelechi K. and Nidorf, Mark and Glinz, Dominik and Nordmann, Alain J. and Briel, Matthias. (2016) Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis. Heart (British Cardiac Society), 102 (8). pp. 590-596.

Hemkens, Lars G. and Ewald, Hannah and Briel, Matthias. (2016) Colchicine and Prevention of Cardiovascular Events. JAMA, 316 (10). pp. 1106-1107.

Hemkens, Lars G. and Ewald, Hannah and Gloy, Viktoria L. and Arpagaus, Armon and Olu, Kelechi K. and Nidorf, Mark and Glinz, Dominik and Nordmann, Alain J. and Briel, Matthias. (2016) Colchicine for prevention of cardiovascular events. The Cochrane database of systematic reviews (1). CD011047.

2015

Hemkens, Lars G. and Ewald, Hannah and Santini-Oliveira, Marilia and Bühler, Julian-Emanuel and Vuichard, Danielle and Schandelmaier, Stefan and Stöckle, Marcel and Briel, Matthias and Bucher, Heiner C.. (2015) Comparative effectiveness of tenofovir in treatment-naïve HIV-infected patients: systematic review and meta-analysis. HIV Clinical Trials, 16 (5). pp. 178-189.

Rosenthal, Rachel and Kasenda, Benjamin and Dell-Kuster, Salome and von Elm, Erik and You, John and Blümle, Anette and Tomonaga, Yuki and Saccilotto, Ramon and Amstutz, Alain and Bengough, Theresa and Meerpohl, Joerg J. and Stegert, Mihaela and Tikkinen, Kari A. O. and Neumann, Ignacio and Carrasco-Labra, Alonso and Faulhaber, Markus and Mulla, Sohail and Mertz, Dominik and Akl, Elie A. and Bassler, Dirk and Busse, Jason W. and Ferreira-González, Ignacio and Lamontagne, Francois and Nordmann, Alain and Gloy, Viktoria and Olu, Kelechi K. and Raatz, Heike and Moja, Lorenzo and Ebrahim, Shanil and Schandelmaier, Stefan and Sun, Xin and Vandvik, Per O. and Johnston, Bradley C. and Walter, Martin A. and Burnand, Bernard and Schwenkglenks, Matthias and Hemkens, Lars G. and Bucher, Heiner C. and Guyatt, Gordon H. and Briel, Matthias. (2015) Completion and Publication Rates of Randomized Controlled Trials in Surgery: An Empirical Study. Annals of Surgery, 262 (1). pp. 68-73.

2014

Kasenda, Benjamin and von Elm, Erik and You, John and Blümle, Anette and Tomonaga, Yuki and Saccilotto, Ramon and Amstutz, Alain and Bengough, Theresa and Meerpohl, Joerg J. and Stegert, Mihaela and Tikkinen, Kari A. O. and Neumann, Ignacio and Carrasco-Labra, Alonso and Faulhaber, Markus and Mulla, Sohail M. and Mertz, Dominik and Akl, Elie A. and Bassler, Dirk and Busse, Jason W. and Ferreira-González, Ignacio and Lamontagne, Francois and Nordmann, Alain and Gloy, Viktoria and Raatz, Heike and Moja, Lorenzo and Rosenthal, Rachel and Ebrahim, Shanil and Schandelmaier, Stefan and Xin, Sun and Vandvik, Per O. and Johnston, Bradley C. and Walter, Martin A. and Burnand, Bernard and Schwenkglenks, Matthias and Hemkens, Lars G. and Bucher, Heiner C. and Guyatt, Gordon H. and Briel, Matthias. (2014) Prevalence, characteristics, and publication of discontinued randomized trials. Journal of the American Medical Association, 311 (10). pp. 1045-1051.

Kasenda, Benjamin and Schandelmaier, Stefan and Sun, Xin and von Elm, Erik and You, John and Blümle, Anette and Tomonaga, Yuki and Saccilotto, Ramon and Amstutz, Alain and Bengough, Theresa and Meerpohl, Joerg J. and Stegert, Mihaela and Olu, Kelechi K. and Tikkinen, Kari A. O. and Neumann, Ignacio and Carrasco-Labra, Alonso and Faulhaber, Markus and Mulla, Sohail M. and Mertz, Dominik and Akl, Elie A. and Bassler, Dirk and Busse, Jason W. and Ferreira-González, Ignacio and Lamontagne, Francois and Nordmann, Alain and Gloy, Viktoria and Raatz, Heike and Moja, Lorenzo and Rosenthal, Rachel and Ebrahim, Shanil and Vandvik, Per O. and Johnston, Bradley C. and Walter, Martin A. and Burnand, Bernard and Schwenkglenks, Matthias and Hemkens, Lars G. and Bucher, Heiner C. and Guyatt, Gordon H. and Briel, Matthias and Disco Study Group, . (2014) Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications. BMJ, 349. g4539.