Treatments for subacute cough in primary care : systematic review and meta-analyses of randomised clinical trials

Speich, Benjamin and Thomer, Anja and Aghlmandi, Soheila and Ewald, Hannah and Zeller, Andreas and Hemkens, Lars G.. (2018) Treatments for subacute cough in primary care : systematic review and meta-analyses of randomised clinical trials. The British journal of general practice, 68 (675). e694-e702.

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Subacute cough following a non-specific viral infection lasting 3-8 weeks is common. However, despite many treatment options there are no systematic reviews evaluating these.; To provide a systematic overview of treatment options and outcomes evaluated in randomised clinical trials (RCTs).; Systematic review and meta-analyses assessing the overall effects of any treatment for subacute cough.; The authors systematically searched PubMed/MEDLINE and the Cochrane Central Register of Controlled Trials (last search March 2017) for RCTs in adult patients with subacute cough. The authors considered trials evaluating any outcome of any drug or non-drug treatments, apart from traditional Chinese and Asian medicines. They combined treatment effects on cough-related outcomes in random effects meta-analyses.; Six eligible RCTs including 724 patients were identified. These assessed montelukast, salbutamol plus ipratropium bromide, gelatine, fluticasone propionate, budesonide, and nociception opioid 1 receptor agonist and codeine. Five studies reported effects on various cough severity scores at various timepoints. No treatment option was associated with a clear benefit on cough recovery or other patient-relevant outcomes in any of the studies or in meta-analyses for cough outcomes at 14 days and 28 days. Reported adverse events were rather mild and reported for 14% of patients across all treatments.; Evidence on treatment options for subacute cough is weak. There is no treatment showing clear patient-relevant benefits in clinical trials.
Faculties and Departments:03 Faculty of Medicine > Departement Klinische Forschung > Clinical Epidemiology and Biostatistics CEB
UniBasel Contributors:Ewald, Hannah and Zeller, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal College of General Practitioners
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 Mar 2022 15:20
Deposited On:15 Nov 2018 13:59

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