Browse by Basel Contributors ID

Tomašič, Tihomir and Rabbani, Said and Jakob, Roman P. and Reisner, Andreas and Jakopin, Žiga and Maier, Timm and Ernst, Beat and Anderluh, Marko. (2021) Does targeting Arg98 of FimH lead to high affinity antagonists? European Journal of Medicinal Chemistry, 211. p. 113093.

Cramer, Jonathan and Aliu, Butrint and Jiang, Xiaohua and Sharpe, Timothy and Pang, Lijuan and Hadorn, Adrian and Rabbani, Said and Ernst, Beat. (2021) Poly-l-lysine Glycoconjugates Inhibit DC-SIGN-mediated Attachment of Pandemic Viruses. ChemMedChem, 16 (15). pp. 2345-2353.

Cramer, Jonathan and Lakkaichi, Adem and Aliu, Butrint and Jakob, Roman P. and Klein, Sebastian and Cattaneo, Ivan and Jiang, Xiaohua and Rabbani, Said and Schwardt, Oliver and Zimmer, Gert and Ciancaglini, Matias and Abreu Mota, Tiago and Maier, Timm and Ernst, Beat. (2021) Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. Journal of the American Chemical Society, 143 (42). pp. 17465-17478.

Cramer, Jonathan and Jiang, Xiaohua and Schönemann, Wojciech and Silbermann, Marleen and Zihlmann, Pascal and Siegrist, Stefan and Fiege, Brigitte and Jakob, Roman Peter and Rabbani, Said and Maier, Timm and Ernst, Beat. (2020) Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding. RSC Chemical Biology, 1 (4). pp. 281-287.

Schönemann, Wojciech and Cramer, Jonathan and Mühlethaler, Tobias and Fiege, Brigitte and Silbermann, Marleen and Rabbani, Said and Dätwyler, Philipp and Zihlmann, Pascal and Jakob, Roman P. and Sager, Christoph P. and Smiesko, Martin and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2019) Improvement of Aglycone π-Stacking Yields Nano- to Subnanomolar FimH Antagonists. ChemMedChem, 14 (7). pp. 749-757.

Rabbani, Said and Fiege, Brigitte and Eris, Deniz and Silbermann, Marleen and Jakob, Roman Peter and Navarra, Giulio and Maier, Timm and Ernst, Beat. (2018) Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain: Engineering a Minimalistic Allosteric System. Journal of Biological Chemistry, 293 (5). pp. 1835-1849.

Sager, Christoph P. and Fiege, Brigitte and Zihlmann, Pascal and Vannam, Raghu and Rabbani, Said and Jakob, Roman P. and Preston, Roland C. and Zalewski, Adam and Maier, Timm and Peczuh, Mark W. and Ernst, Beat. (2018) The price of flexibility - a case study on septanoses as pyranose mimetics. Chemical Science, 9 (3). pp. 646-654.

Zihlmann, Pascal and Silbermann, Marleen and Sharpe, Timothy and Jiang, Xiaohua and Mühlethaler, Tobias and Jakob, Roman P. and Rabbani, Said and Sager, Christoph P. and Frei, Priska and Pang, Lijuan and Maier, Timm and Ernst, Beat. (2018) KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany), 24. pp. 1-10.

Schönemann, Wojciech and Lindegger, Marcel and Rabbani, Said and Zihlmann, Pascal. (2017) 2-C-Branced mannosides as a novel family of FimH antagonists - Synthesis and biological evaluation. Perspectives in Science, 11. pp. 53-61.

Rabbani, Said and Krammer, Eva-Maria and Goedele, Roos and Zalewski, Adam and Preston, Roland and Eid, Sameh and Zihlmann, Pascal and Prévost, Martine and Lensink, Marc F. and Thompson, Andrew and Ernst, Beat and Bouckaert, Julie. (2017) Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IU Cr J, 4 (1). pp. 7-23.

Navarra, Giulio and Zihlmann, Pascal and Jakob, Roman P. and Stangier, Katia and Preston, Roland C. and Rabbani, Said and Smiesko, Martin and Wagner, Bea and Maier, Timm and Ernst, Beat. (2017) Carbohydrate-Lectin Interactions - An Unexpected Contribution to Affinity. ChemBioChem, 18 (6). pp. 539-544.

Pang, Lijuan and Bezençon, Jacqueline and Kleeb, Simon and Rabbani, Said and Sigl, Anja and Smiesko, Martin and Sager, Christoph P. and Eris, Deniz and Schwardt, Oliver and Ernst, Beat. (2017) FimH antagonists - solubility vs. permeability. In: Carbohydrate Chemistry. London, pp. 248-273.

Mayer, Katharina and Eris, Deniz and Schwardt, Oliver and Sager, Christoph P. and Rabbani, Said and Kleeb, Simon and Ernst, Beat. (2017) Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant? Journal of Medicinal Chemistry, 60 (13). pp. 5646-5662.

Wipf, Mathias and Stoop, Ralph L. and Navarra, Giulio and Rabbani, Said and Ernst, Beat and Bedner, Kristine and Schonenberger, Christian and Calame, Michel. (2016) Label-Free FimH Protein Interaction Analysis Using Silicon Nanoribbon BioFETs. ACS Sensors, 1 (6). pp. 781-788.

Pröpster, Johannes M. and Yang, Fan and Rabbani, Said and Ernst, Beat and Allain, Frédéric H.-T. and Schubert, Mario. (2016) Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8. Proceedings of the National Academy of Sciences of the United States of America, 113 (29). pp. 4170-4179.

Kleeb, Simon and Pang, Lijuan and Mayer, Katharina and Eris, Deniz and Sigl, Anja and Preston, Roland C. and Zihlmann, Pascal and Sharpe, Timothy and Jakob, Roman P. and Abgottspon, Daniela and Hutter, Aline S. and Scharenberg, Meike and Jiang, Xiaohua and Navarra, Giulio and Rabbani, Said and Smiesko, Martin and Lüdin, Nathalie and Bezençon, Jacqueline and Schwardt, Oliver and Maier, Timm and Ernst, Beat. (2015) FimH Antagonists: Bioisosteres To Improve the in Vitro and in Vivo PK/PD Profile. Journal of Medicinal Chemistry, 58 (5). pp. 2221-2239.

Fiege, Brigitte and Rabbani, Said and Preston, Roland C. and Jakob, Roman P. and Zihlmann, Pascal and Schwardt, Oliver and Jiang, Xiaohua and Maier, Timm and Ernst, Beat. (2015) The Tyrosine Gate of the Bacterial Lectin FimH : a Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. ChemBioChem, 16 (8). pp. 1235-1246.

Preston, Roland C. and Rabbani, Said and Binder, Florian P. C. and Moes, Suzette and Magnani, John L. and Ernst, Beat. (2014) Implications of the E-selectin S128R mutation for drug discovery. Glycobiology, 24 (7). pp. 592-601.

Tomasic, Tihomir and Rabbani, Said and Gobec, Martina and Mlinaric Rascan, Irena and Podlipnik, Crtomir and Ernst, Beat and Anderluh, Marko. (2014) Branched α-D-mannopyranosides : a new class of potent FimH antagonists. MedChemComm , 5 (8). pp. 1247-1253.

Zierke, Mirko and Smiesko, Martin and Rabbani, Said and Aeschbacher, Thomas and Cutting, Brian and Allain, Frédéric H.-T. and Schubert, Mario and Ernst, Beat. (2013) Stabilization of branched oligosaccharides : Lewisx benefits from a non-conventional C-H...O hydrogen bond. Journal of the American Chemical Society, 135 (36). pp. 13464-13472.

Egger, Jonas and Weckerle, Céline and Cutting, Brian and Schwardt, Oliver and Rabbani, Said and Lemme, Katrin and Ernst, Beat. (2013) Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. Journal of the American Chemical Society, 135 (26). pp. 9820-9828.

Scharenberg, Meike and Jiang, Xiaohua and Pang, Lijuan and Navarra, Giulio and Rabbani, Said and Binder, Florian and Schwardt, Oliver and Ernst, Beat. (2013) Kinetic properties of carbohydrate–lectin interactions: FimH antagonists. ChemMedChem, 9 (1). pp. 78-83.

Schwizer, Daniel and Patton, John T. and Cutting, Brian and Smiesko, Martin and Wagner, Beatrice and Kato, Ako and Weckerle, Céline and Binder, Florian P. C. and Rabbani, Said and Schwardt, Oliver and Magnani, John L. and Ernst, Beat. (2012) Pre-organization of the core structure of E-selectin antagonists. Chemistry - A European Journal, 18 (5). pp. 1342-1351.

Pang, Lijuan and Kleeb, Simon and Lemme, Katrin and Rabbani, Said and Scharenberg, Meike and Zalewski, Adam and Schädler, Florentina and Schwardt, Oliver and Ernst, Beat. (2012) FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides. ChemMedChem, 7 (8). pp. 1404-1422.

Jiang, Xiaohua and Abgottspon, Daniela and Kleeb, Simon and Rabbani, Said and Scharenberg, Meike and Wittwer, Matthias and Haug, Martina and Schwardt, Oliver and Ernst, Beat. (2012) Anti-adhesion therapy for urinary tract infections - a balanced PK/PD-profile proved to be key for success. Journal of Medicinal Chemistry, 55 (10). pp. 4700-4713.

Galan, M. Carmen and Tran, Anh Tuan and Bromfield, Karen and Rabbani, Said and Ernst, Beat. (2012) Ionic-liquid-based MS probes for the chemo-enzymatic synthesis of oligosaccharides. Organic and Biomolecular Chemistry, 10 (35). pp. 7091-7097.

Schwardt, Oliver and Rabbani, Said and Hartmann, Margrit and Abgottspon, Daniela and Wittwer, Matthias and Kleeb, Simon and Zalewski, Adam and Smiesko, Martin and Cutting, Brian and Ernst, Beat. (2011) Design, Synthesis and Biological Evaluation of Mannosyl Triazoles as FimH Antagonists. Bioorganic & Medicinal Chemistry, 19 (21). pp. 6454-6473.

Scharenberg, Meike and Abgottspon, Daniela and Cicek, Evelin and Jiang, Xiaohua and Schwardt, Oliver and Rabbani, Said and Ernst, Beat. (2011) A Flow Cytometry-based Assay for Screening FimH Antagonists. Assay and Drug Development Technologies, 9 (5). pp. 455-464.

Mesch, Stefanie and Moser, D. and Strasser, Daniel and Kelm, A. and Cutting, Brian and Rossato, Gianluca and Vedani, Angelo and Koliwer-Brandl, H. and Wittwer, Matthias and Rabbani, Said and Schwardt, Oliver and Kelm, S. and Ernst Beat, . (2010) Low Molecular Weight Antagonists of the Myelin-associated Glycoprotein : Synthesis, Docking and Biological Evaluation. Journal of Medicinal Chemistry, Vol. 53, no. 4. pp. 1597-1615.

Rabbani, Said and Jiang, Xiaohua and Schwardt, Oliver and Ernst, Beat. (2010) Expression of the Carbohydrate Recognition Domain of FimH and Development of a Competitive Binding Assay. Analytical Biochemistry , 407. pp. 188-195.

Klein, Tobias and Abgottspon, Daniela and Wittwer, Matthias and Rabbani, Said and Herold, Janno and Jiang, Xiaohua and Kleeb, Simon and Lüthi, Christine and Scharenberg, Meike and Bezençcon, Jacqueline and Gubler, Erich and Pang, Lijuan and Smiesko, Martin and Cutting, Brian and Schwardt, Oliver and Ernst, Beat. (2010) FimH Antagonists for the Oral Treatment of Urinary Tract Infections : From Design and Synthesis to In Vitro and In Vivo Evaluation. Journal of Medicinal Chemistry, 53 (24). pp. 8627-8641.

Stokmaier, Daniela and Khorev, Oleg and Böni, F. and Gentner, M. and Cutting, Brian and Born, Rita and Schwingruber, K. and Ernst, T. O. G. and Wittwer, Matthias and Ricklin, Daniel and Spreafico, Morena and Vedani, Angelo and Rabbani, Said and Schwardt, Oliver and Ernst, Beat. (2009) Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorganic & Medicinal Chemistry, 17 (20). pp. 7254-7264.

Rabbani, Said and Corona, F. and Ernst Beat, . (2009) Biochemical Characterization of Helicobacter pylori a-1-4 Fucosyltransferase : Metal Ion Requirement, Donor Substrate Specificity and Organic Solvent Stability. Biometals, Vol. 22, no. 6. pp. 1011-1017.