Identification of xenobiotics interfering with corticosteroid - androgen balance

Kędzierski, Jacek. Identification of xenobiotics interfering with corticosteroid - androgen balance. 2023, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: https://edoc.unibas.ch/96095/

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The preset in this thesis research provides valuable insights into the complex interplay between xenobiotics and corticosteroids-androgens balance. Through an extensive review of the literature, experimental investigations, and data analysis, several important conclusions emerge. The presented research confirms that xenobiotics, such as drugs interfere with the delicate balance between corticosteroids and androgens in the human body. This interference has profound implications for overall health and well-being. Xenobiotics interfere with corticosteroid-androgen balance through altering enzyme activity which in turn affects hormone synthesis and metabolism. This impact underscored the need for a comprehensive understanding of pathways involving AKR1D1, SRD5A2, CYP11B1, and CYP17A1 and the development of effective screening platforms. The findings regarding anabolic-androgenic steroids, Zardawerine, MK-0773, azole fungicides, and others emphasize the clinical relevance of studying xenobiotics and their impact on hormonal balance. These disruptions contribute to the development of various health conditions, such as endocrine disorders, metabolic disturbances, and reproductive issues.
Advisors:Smiesko, Martin
Committee Members:Meyer zu Schwabedissen, Henriette and Tetko, Igor V
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Biopharmacy (Meyer zu Schwabedissen)
UniBasel Contributors:Kedzierski, Jacek and Smiesko, Martin
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:15240
Thesis status:Complete
Number of Pages:145
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss152402
edoc DOI:
Last Modified:17 Jan 2024 05:30
Deposited On:16 Jan 2024 09:37

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