Identification of xenobiotics interfering with corticosteroid - androgen balance

The preset in this thesis research provides valuable insights into the complex interplay between xenobiotics and corticosteroids-androgens balance. Through an extensive review of the literature, experimental investigations, and data analysis, several important conclusions emerge. The presented research confirms that xenobiotics, such as drugs interfere with the delicate balance between corticosteroids and androgens in the human body. This interference has profound implications for overall health and well-being. Xenobiotics interfere with corticosteroid-androgen balance through altering enzyme activity which in turn affects hormone synthesis and metabolism. This impact underscored the need for a comprehensive understanding of pathways involving AKR1D1, SRD5A2, CYP11B1, and CYP17A1 and the development of effective screening platforms. The findings regarding anabolic-androgenic steroids, Zardawerine, MK-0773, azole fungicides, and others emphasize the clinical relevance of studying xenobiotics and their impact on hormonal balance. These disruptions contribute to the development of various health conditions, such as endocrine disorders, metabolic disturbances, and reproductive issues.