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Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients

Bibert, Stéphanie and Guex, Nicolas and Lourenco, Joao and Brahier, Thomas and Papadimitriou-Olivgeris, Matthaios and Damonti, Lauro and Manuel, Oriol and Liechti, Robin and Götz, Lou and Tschopp, Jonathan and Quinodoz, Mathieu and Vollenweider, Peter and Pagani, Jean-Luc and Oddo, Mauro and Hügli, Olivier and Lamoth, Frédéric and Erard, Véronique and Voide, Cathy and Delorenzi, Mauro and Rufer, Nathalie and Candotti, Fabio and Rivolta, Carlo and Boillat-Blanco, Noémie and Bochud, Pierre-Yves and RegCovid Study Group, . (2021) Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients. Frontiers in Immunology, 12. p. 666163.

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Abstract

The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19.
Faculties and Departments:09 Associated Institutions > Institute of Molecular and Clinical Ophthalmology Basel (IOB) > Research Group Rivolta IOB
UniBasel Contributors:Rivolta, Carlo
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
e-ISSN:1664-3224
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:11 Sep 2023 07:31
Deposited On:11 Sep 2023 07:31

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