Steiner, Rebekah. TLR9-ligation in naive B cells activates NF-κB and PKM2 tetramer shift for glycolytic reprogramming and TNF expression. 2023, Doctoral Thesis, University of Basel, Faculty of Science.
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Abstract
The innate-like function of B cell is dependent on pattern recognition receptors, such as Toll-like receptors (TLR). TLR ligation and activation of downstream signaling pathways drives metabolic changes in cells and promotes effector functions (e.g., cytokine secretion). However, the immunometabolic profile of B cells during the initial recognition of pathogen associated molecular patterns via Toll-like receptor 9 in the innate immune response is limited. TLR9-activation in B cells by CpG elicits an increased glycolytic response mediated by NF-κB, which in and of itself is a strong mediator of metabolism and immune function. However, we further define the role of NF-kB mediated metabolic switch to facilitate a temporal shift in PKM2 tetramerization status sensitive to IKK inhibition that induces B cell expression of TNF (Figure 1).
Advisors: | Hess, Christoph |
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Committee Members: | Pieters, Jean and Jellusova, Julia |
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunobiology (Hess C) 05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters) |
UniBasel Contributors: | Hess, Christoph and Pieters, Jean |
Item Type: | Thesis |
Thesis Subtype: | Doctoral Thesis |
Thesis no: | 15070 |
Thesis status: | Complete |
Number of Pages: | 125 |
Language: | English |
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edoc DOI: | |
Last Modified: | 01 Sep 2024 01:30 |
Deposited On: | 01 Sep 2023 07:58 |
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