Marx, Anna-Friederike Marx. The role of residual antigen and of the alarmin IL-33 in shaping the antiviral immune response. 2021, Doctoral Thesis, University of Basel, Faculty of Science.
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Abstract
The aims of the thesis were threefold:
Firstly, we were interested in studying the potency of residual LCMV antigen-depots in transiently CD4 T cell depleted mice for the induction of an antiviral B cell response.
Secondly, we studied whether a heterologous arenavirus vector prime-boost was beneficial for the establishment of an effective tumor-specific CD8 T cell response.
Thirdly, we aimed to define the role of the IL-33 ST2 axis for the formation of an anti-viral CD8 T cell response in the context of a chronic viral infection.
Firstly, we were interested in studying the potency of residual LCMV antigen-depots in transiently CD4 T cell depleted mice for the induction of an antiviral B cell response.
Secondly, we studied whether a heterologous arenavirus vector prime-boost was beneficial for the establishment of an effective tumor-specific CD8 T cell response.
Thirdly, we aimed to define the role of the IL-33 ST2 axis for the formation of an anti-viral CD8 T cell response in the context of a chronic viral infection.
| Advisors: | Pinschewer, Daniel |
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| Committee Members: | Dehio, Christoph and Aichele, Peter |
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Experimental Virology (Pinschewer) 05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Dehio) |
| UniBasel Contributors: | Marx, Anna-Friederike and Pinschewer, Daniel and Dehio, Christoph |
| Item Type: | Thesis |
| Thesis Subtype: | Doctoral Thesis |
| Thesis no: | 15041 |
| Thesis status: | Complete |
| Number of Pages: | 160 |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 23 Jun 2023 04:30 |
| Deposited On: | 22 Jun 2023 13:18 |
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