Atomic force microscopy-based characterization and design of biointerfaces

Alsteens, David and Gaub, Hermann E. and Newton, Richard and Pfreundschuh, Moritz and Gerber, Christoph and Müller, Daniel J.. (2017) Atomic force microscopy-based characterization and design of biointerfaces. Nature Reviews Materials, 2 (5). p. 17008.

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Official URL: https://edoc.unibas.ch/94609/

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Atomic force microscopy (AFM)-based methods have matured into a powerful nanoscopic platform, enabling the characterization of a wide range of biological and synthetic biointerfaces ranging from tissues, cells, membranes, proteins, nucleic acids and functional materials. Although the unprecedented signal-to-noise ratio of AFM enables the imaging of biological interfaces from the cellular to the molecular scale, AFM-based force spectroscopy allows their mechanical, chemical, conductive or electrostatic, and biological properties to be probed. The combination of AFM-based imaging and spectroscopy structurally maps these properties and allows their 3D manipulation with molecular precision. In this Review, we survey basic and advanced AFM-related approaches and evaluate their unique advantages and limitations in imaging, sensing, parameterizing and designing biointerfaces. It is anticipated that in the next decade these AFM-related techniques will have a profound influence on the way researchers view, characterize and construct biointerfaces, thereby helping to solve and address fundamental challenges that cannot be addressed with other techniques.
Faculties and Departments:05 Faculty of Science > Departement Physik > Physik > Nanomechanik (Meyer)
UniBasel Contributors:Gerber, Christoph
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Nature Research
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:24 May 2023 08:25
Deposited On:24 May 2023 08:25

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