DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles

Overwijn, Daan and Hondele, Maria. (2022) DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles. Trends in Biochemical Sciences, 48 (3). pp. 244-258.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/93704/

Downloads: Statistics Overview


RNA-dependent DEAD-box ATPases (DDXs) are emerging as major regulators of RNA-containing membrane-less organelles (MLOs). On the one hand, oligomerizing DDXs can promote condensate formation 'in cis', often using RNA as a scaffold. On the other hand, DDXs can disrupt RNA-RNA and RNA-protein interactions and thereby 'in trans' remodel the multivalent interactions underlying MLO formation. In this review, we discuss the best studied examples of DDXs modulating MLOs in cis and in trans. Further, we illustrate how this contributes to the dynamic assembly and turnover of MLOs which might help cells to modulate RNA sequestration and processing in a temporal and spatial manner.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hondele)
UniBasel Contributors:Hondele, Maria and Overwijn, Daan
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2023 10:35
Deposited On:27 Mar 2023 10:35

Repository Staff Only: item control page