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Priming and activation of mouse macrophages by trehalose 6,6'-dicorynomycolate vesicles from Corynebacterium glutamicum

Chami, Mohamed and Andréau, Karine and Lemassu, Anne and Petit, Jean-François and Houssin, Christine and Puech, Virginie and Bayan, Nicolas and Chaby, Richard and Daffé, Mamadou. (2002) Priming and activation of mouse macrophages by trehalose 6,6'-dicorynomycolate vesicles from Corynebacterium glutamicum. FEMS Immunology and Medical Microbiology, 32 (2). pp. 141-147.

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Official URL: https://edoc.unibas.ch/93670/

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Abstract

Vesicles consisting of pure trehalose dicorynomycolate (TDCM), the corynebacterial analog of the most studied mycobacterial glycolipid 'cord factor', were isolated from Corynebacterium glutamicum cells by mild detergent treatment; these induced in vivo a macrophage priming similar to that obtained with mycobacterial-derived trehalose dimycolate. In vitro, both TDCM and bacterial lipopolysaccharide (LPS) induced in macrophages the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), endotoxin tolerance, and were primed for an enhanced secondary NO response to LPS. Interferon-gamma pretreatment did not influence the LPS-induced TNF-alpha response, but considerably increased the TDCM-induced response.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > BioEM Lab (Chami)
UniBasel Contributors:Chami, Mohamed and Engel, Andreas H
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0928-8244
e-ISSN:1574-695X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Feb 2023 15:20
Deposited On:21 Feb 2023 14:49

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