Bacterial Degradation of Nτ-Methylhistidine

Beliaeva, Mariia A. and Atac, Reyhan and Seebeck, Florian P.. (2022) Bacterial Degradation of Nτ-Methylhistidine. ACS Chemical Biology, 17 (7). pp. 1989-1995.

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Official URL: https://edoc.unibas.ch/92286/

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The first three enzymatic steps by which organisms degrade histidine are universally conserved. A histidine ammonia-lyase (EC catalyzes 1,2-elimination of the α-amino group from l-histidine; a urocanate hydratase (EC converts urocanate to 4-imidazolone-5-propionate, and this intermediate is hydrolyzed to; N; -formimino-l; -; glutamate by an imidazolonepropionase (EC Surprisingly, despite broad distribution in many species from all kingdoms of life, this pathway has rarely served as a template for the evolution of other metabolic processes. The only other known pathway with a similar logic is that of ergothioneine degradation. In this report, we describe a new addition to this exclusive collection. We show that the firmicute; Bacillus terra; and other soil-dwelling bacteria contain enzymes for the degradation of; N; τ-methylhistidine to l-glutamate and; N; -methylformamide. Our results indicate that in some environments,; N; τ-methylhistidine can accumulate to concentrations that make its efficient degradation a competitive skill. In addition, this process describes the first biogenic source of; N; -methylformamide.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Organische Chemie (Gademann)
UniBasel Contributors:Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Jan 2023 07:59
Deposited On:11 Jan 2023 07:59

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