Spatio-Temporal Recruitment of Adult Neural Stem Cells for Transient Neurogenesis During Pregnancy

Chaker, Zayna and Segalada, Corina and Doetsch, Fiona. (2021) Spatio-Temporal Recruitment of Adult Neural Stem Cells for Transient Neurogenesis During Pregnancy.

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Official URL: https://edoc.unibas.ch/91766/

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Neural stem cells (NSCs) in the adult mouse brain contribute to lifelong brain plasticity. NSCs in the adult ventricular-subventricular zone (V-SVZ) are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb interneurons. Here, we show that during pregnancy multiple regionally-distinct NSCs are dynamically recruited at different times. Coordinated temporal activation of these NSC pools generates sequential waves of short-lived olfactory bulb interneuron subtypes that mature in the mother around birth and in the perinatal care period. Concomitant with neuronal addition, oligodendrocyte progenitors also transiently increase in the olfactory bulb. Thus, life experiences, such as pregnancy, can trigger transient neurogenesis and gliogenesis under tight spatial and temporal control, and may provide a novel substrate for brain plasticity in anticipation of temporary physiological demand.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona and Chaker, Zayna and Segalada, Corina Gabriela
Item Type:Preprint
Note:Publication type according to Uni Basel Research Database: Discussion paper / Internet publication
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Last Modified:09 Jan 2023 10:56
Deposited On:21 Dec 2022 08:34

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