Current Perspectives on Synthetic Compartments for Biomedical Applications

Heuberger, Lukas and Korpidou, Maria and Eggenberger, Olivia M. and Kyropoulou, Myrto and Palivan, Cornelia G.. (2022) Current Perspectives on Synthetic Compartments for Biomedical Applications. International Journal of Molecular Sciences, 23 (10). p. 5718.

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Official URL: https://edoc.unibas.ch/91526/

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Nano- and micrometer-sized compartments composed of synthetic polymers are designed to mimic spatial and temporal divisions found in nature. Self-assembly of polymers into compartments such as polymersomes, giant unilamellar vesicles (GUVs), layer-by-layer (LbL) capsules, capsosomes, or polyion complex vesicles (PICsomes) allows for the separation of defined environments from the exterior. These compartments can be further engineered through the incorporation of (bio)molecules within the lumen or into the membrane, while the membrane can be decorated with functional moieties to produce catalytic compartments with defined structures and functions. Nanometer-sized compartments are used for imaging, theranostic, and therapeutic applications as a more mechanically stable alternative to liposomes, and through the encapsulation of catalytic molecules, i.e., enzymes, catalytic compartments can localize and act in vivo. On the micrometer scale, such biohybrid systems are used to encapsulate model proteins and form multicompartmentalized structures through the combination of multiple compartments, reaching closer to the creation of artificial organelles and cells. Significant progress in therapeutic applications and modeling strategies has been achieved through both the creation of polymers with tailored properties and functionalizations and novel techniques for their assembly.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Kyropoulou, Myrto and Heuberger, Lukas Raphael and Korpidou, Maria and Eggenberger, Olivia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Dec 2022 09:00
Deposited On:15 Dec 2022 09:00

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