Overview: Mycobacterium ulcerans disease (buruli ulcer)

Röltgen, Katharina and Pluschke, Gerd. (2022) Overview: Mycobacterium ulcerans disease (buruli ulcer). In: Mycobacterium ulcerans: methods and protocols. New York, NY, pp. 3-6.

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Enhanced international research efforts since the establishment of the Global BU Initiative in 1998 by the WHO have helped to advance our understanding of the epidemiology, and pathogenesis of Mycobacterium ulcerans infections. Improved methods to cultivate the extremely slow-growing pathogen from BU lesions have laid the groundwork for a variety of studies using M. ulcerans isolates, including the analysis of the genome and proteome of the pathogen, as well as drug susceptibility testing and analyses of host-pathogen interactions in vitro and in animal models. The identification of specific, high-copy number target sequences in the genome of M. ulcerans has enabled the development of diagnostic tests and assays to detect the pathogen in the environment. Important research questions remain about the reservoir(s) of M. ulcerans in aquatic environments, factors leading to or promoting transmission to hosts, and host-pathogen interactions resulting in chronic infection versus spontaneous healing.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Molecular Immunology (Pluschke)
UniBasel Contributors:Pluschke, Gerd
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Series Name:Methods in Molecular Biology
Issue Number:2387
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:06 Sep 2023 15:42
Deposited On:27 Dec 2022 16:51

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