Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

Mukhtar, Tanzila and Breda, Jeremie and Adam, Manal A. and Boareto, Marcelo and Grobecker, Pascal and Karimaddini, Zahra and Grison, Alice and Eschbach, Katja and Chandrasekhar, Ramakrishnan and Vermeul, Swen and Okoniewski, Michal and Pachkov, Mikhail and Harwell, Corey C. and Atanasoski, Suzana and Beisel, Christian and Iber, Dagmar and van Nimwegen, Erik and Taylor, Verdon. (2022) Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis. The EMBO Journal. e111132.

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Official URL: https://edoc.unibas.ch/91272/

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The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Embryology and Stem Cell Biology (Taylor)
05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (van Nimwegen)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Cellular Neurobiology (Atanasoski)
UniBasel Contributors:van Nimwegen, Erik and Breda, Jeremie and Grobecker, Pascal and Pachkov, Mikhail and Mukhtar, Tanzila and Grison, Alice and Taylor, Verdon and Atanasoski, Suzana
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Apr 2023 03:10
Deposited On:13 Dec 2022 14:47

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