Reichmuth, M. L. and Homke, R. and Zürcher, K. and Sander, P. and Avihingsanon, A. and Collantes, J. and Loiseau, C. and Borrell, S. and Reinhard, M. and Wilkinson, R. J. and Yotebieng, M. and Fenner, L. and Böttger, E. C. and Gagneux, S. and Egger, M. and Keller, P. M. and International epidemiology Databases to Evaluate Aids, . (2020) Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naïve patients. Antimicrob Agents Chemother, 64 (11). e00513-20.
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Official URL: https://edoc.unibas.ch/91215/
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Abstract
Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical MIC to delamanid.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux) |
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| UniBasel Contributors: | Loiseau, Chloé Marie and Borrell Farnov, Sonia and Reinhard, Miriam and Gagneux, Sebastien |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1098-6596 (Electronic)0066-4804 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 27 Dec 2022 16:26 |
| Deposited On: | 27 Dec 2022 16:26 |
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