Seebacher, W. and Mohsin, N. U. A. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Schuster, D. and Temml, V. and Weis, R.. (2021) Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies. Monatshefte fuÌ�r Chemie, 152. pp. 1347-1359.
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Abstract
The antiprotozoal activity of 1-benzyltetrahydropyridin-4-yliden iminium salts is reported. This paper describes the preparation of a series of analogs from dihydropyridines or dihydrothiopyrans as educts. The new compounds were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis (sleeping sickness). Several structure-activity relationships were detected. Both the substituents in ring positions 1 and 4 of the tetrahydropyridinium moiety had a strong impact on the antiprotozoal activities as well as on the cytotoxicity of compounds against L-6 cells (rat skeletal myoblasts). All new compounds were characterized using FT-IR spectroscopy, HRMS, and NMR spectroscopy.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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UniBasel Contributors: | Kaiser, Marcel and Mäser, Pascal |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
ISSN: | 0026-9247 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
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edoc DOI: | |
Last Modified: | 21 Dec 2022 10:28 |
Deposited On: | 21 Dec 2022 10:28 |
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