Leas, D. A. and Sanford, A. G. and Wu, J. and Cal, M. and Kaiser, M. and Wittlin, S. and Hemsley, R. M. and Darner, E. B. and Lui, L. M. and Davis, P. H. and Vennerstrom, J. L.. (2021) Diaryl ureas as an antiprotozoal chemotype. ACS Infect Dis, 7 (6). pp. 1578-1583.
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Official URL: https://edoc.unibas.ch/89175/
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Abstract
We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N'-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models of malaria and toxoplasmosis.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Cal, Monica and Kaiser, Marcel and Wittlin, Sergio |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 2373-8227 (Electronic)2373-8227 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 20 Dec 2022 12:20 |
| Deposited On: | 20 Dec 2022 12:20 |
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