Ley, S. D. and Pillay, S. and Streicher, E. M. and van der Heijden, Y. F. and Sirgel, F. and Derendinger, B. and de Kock, M. and Gagneux, S. and Warren, R. M. and Theron, G. and de Vos, M.. (2021) Melting the eis: non-detection of kanamycin resistance markers by routine diagnostic tests and identification of new eis-promoter variants. Antimicrob Agents Chemother, 65 (7). e0250220.
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Official URL: https://edoc.unibas.ch/89166/
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Abstract
Eis-promoter mutations can confer reduced Mycobacterium tuberculosis kanamycin susceptibility. GenoType MTBDRsl, a widely used assay evaluating this region, wrongly classified 17/410 isolates as eis-promoter wildtype. 6/17 isolates harbored mutations known to confer kanamycin resistance, and the remainder harbored either novel eis-promoter mutations (7/11) or disputed mutations (4/11). GenoType MTBDRsl can miss established and new variants that cause reduced susceptibility. These data highlight the importance of reflex phenotypic kanamycin testing.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux) |
|---|---|
| UniBasel Contributors: | Ley, Serej and Gagneux, Sebastien |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1098-6596 (Electronic)0066-4804 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 20 Dec 2022 12:11 |
| Deposited On: | 20 Dec 2022 12:11 |
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