Transcription factor motif activity as a biomarker of muscle aging

Börsch, Anastasiya and Zavolan, Mihaela. (2021) Transcription factor motif activity as a biomarker of muscle aging. American journal of aging science and research, 2 (1). pp. 19-23.

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Official URL: https://edoc.unibas.ch/88158/

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In prior work, we analyzed gene expression profiles of mouse, rat and human gastrocnemius muscles to identify conserved regulators of muscle aging processes. By further comparing data obtained from different muscles we found stronger conservation of aging-related factors at the level of molecular pathways than at the level of individual genes. Here we compared the predictive power of models based on gene expression levels and those based on transcription factor motif activities for an individual's age. Although somewhat less accurate than models based on gene expression, models based on motif activities achieve good prediction of muscle age, further providing insights into aging-related molecular pathways.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
UniBasel Contributors:Zavolan, Mihaela and Börsch, Anastasiya
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Apr 2022 10:17
Deposited On:13 Apr 2022 10:17

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