Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

Wong, Gerard C. L. and Antani, Jyot D. and Lele, Pushkar P. and Chen, Jing and Nan, Beiyan and Kühn, Marco J. and Persat, Alexandre and Bru, Jean-Louis and Molin Høyland-Kroghsbo, Nina and Siryaporn, Albert and Conrad, Jacinta C. and Carrara, Francesco and Yawata, Yutaka and Stocker, Roman and Brun, Yves V. and Whitfield, Gregory B. and Lee, Calvin K. and de Anda, Jaime and Schmidt, William C. and Golestanian, Ramin and O'Toole, George A. and Floyd, Kyle A. and Yildiz, Fitnat H. and Yang, Shuai and Jin, Fan and Toyofuku, Masanori and Eberl, Leo and Nomura, Nobuhiko and Zacharoff, Lori A. and El-Naggar, Mohamed Y. and Yalcin, Sibel Ebru and Malvankar, Nikhil S. and Rojas-Andrade, Mauricio D. and Hochbaum, Allon I. and Yan, Jing and Stone, Howard A. and Wingreen, Ned S. and Bassler, Bonnie L. and Wu, Yilin and Xu, Haoran and Drescher, Knut and Dunkel, Jörn. (2021) Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Physical biology, 18 (5). 051501.

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Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising behavior. Bacterial biofilms are more than the sum of their parts: single-cell behavior has a complex relation to collective community behavior, in a manner perhaps cognate to the complex relation between atomic physics and condensed matter physics. Biofilm microbiology is a relatively young field by biology standards, but it has already attracted intense attention from physicists. Sometimes, this attention takes the form of seeing biofilms as inspiration for new physics. In this roadmap, we highlight the work of those who have taken the opposite strategy: we highlight the work of physicists and physical scientists who use physics to engage fundamental concepts in bacterial biofilm microbiology, including adhesion, sensing, motility, signaling, memory, energy flow, community formation and cooperativity. These contributions are juxtaposed with microbiologists who have made recent important discoveries on bacterial biofilms using state-of-the-art physical methods. The contributions to this roadmap exemplify how well physics and biology can be combined to achieve a new synthesis, rather than just a division of labor.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
UniBasel Contributors:Drescher, Knut
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Institute of Physics Publishing (IOP)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Mar 2022 09:54
Deposited On:09 Mar 2022 09:54

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