Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain

Delgado, Ana C. and Maldonado-Soto, Angel R. and Silva-Vargas, Violeta and Mizrak, Dogukan and von Känel, Thomas and Tan, Kelly R. and Paul, Alex and Madar, Aviv and Cuervo, Henar and Kitajewski, Jan and Lin, Chyuan-Sheng and Doetsch, Fiona. (2021) Release of stem cells from quiescence reveals gliogenic domains in the adult mouse brain. Science (New York, N.Y.), 372 (6547). pp. 1205-1209.

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Official URL: https://edoc.unibas.ch/85336/

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Quiescent neural stem cells (NSCs) in the adult mouse ventricular-subventricular zone (V-SVZ) undergo activation to generate neurons and some glia. Here we show that platelet-derived growth factor receptor beta (PDGFRβ) is expressed by adult V-SVZ NSCs that generate olfactory bulb interneurons and glia. Selective deletion of PDGFRβ in adult V-SVZ NSCs leads to their release from quiescence, uncovering gliogenic domains for different glial cell types. These domains are also recruited upon injury. We identify an intraventricular oligodendrocyte progenitor derived from NSCs inside the brain ventricles that contacts supraependymal axons. Together, our findings reveal that the adult V-SVZ contains spatial domains for gliogenesis, in addition to those for neurogenesis. These gliogenic NSC domains tend to be quiescent under homeostasis and may contribute to brain plasticity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona and Delgado Fumero, Ana and Silva Vargas, Violeta and von Känel, Thomas and Tan, Kelly
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Dec 2021 08:28
Deposited On:03 Dec 2021 07:57

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