Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

Benschop, Kimberley S. M. and Broberg, Eeva K. and Hodcroft, Emma and Schmitz, Dennis and Albert, Jan and Baicus, Anda and Bailly, Jean-Luc and Baldvinsdottir, Gudrun and Berginc, Natasa and Blomqvist, Soile and Böttcher, Sindy and Brytting, Mia and Bujaki, Erika and Cabrerizo, Maria and Celma, Cristina and Cinek, Ondrej and Claas, Eric C. J. and Cremer, Jeroen and Dean, Jonathan and Dembinski, Jennifer L. and Demchyshyna, Iryna and Diedrich, Sabine and Dudman, Susanne and Dunning, Jake and Dyrdak, Robert and Emmanouil, Mary and Farkas, Agnes and De Gascun, Cillian and Fournier, Guillaume and Georgieva, Irina and Gonzalez-Sanz, Ruben and van Hooydonk-Elving, Jolanda and Jääskeläinen, Anne J. and Jancauskaite, Ruta and Keeren, Kathrin and Fischer, Thea K. and Krokstad, Sidsel and Nikolaeva-Glomb, Lubomira and Novakova, Ludmila and Midgley, Sofie E. and Mirand, Audrey and Molenkamp, Richard and Morley, Ursula and Mossong, Joël and Muralyte, Svajune and Murk, Jean-Luc and Nguyen, Trung and Nordbø, Svein A. and Österback, Riikka and Pas, Suzan and Pellegrinelli, Laura and Pogka, Vassiliki and Prochazka, Birgit and Rainetova, Petra and Van Ranst, Marc and Roorda, Lieuwe and Schuffenecker, Isabelle and Schuurman, Rob and Stoyanova, Asya and Templeton, Kate and Verweij, Jaco J. and Voulgari-Kokota, Androniki and Vuorinen, Tytti and Wollants, Elke and Wolthers, Katja C. and Zakikhany, Katherina and Neher, Richard and Harvala, Heli and Simmonds, Peter. (2021) Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. Emerging infectious diseases, 27 (6). pp. 1616-1626.

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Abstract

In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected persons 0-4 years of age (29%) and 25-34 years of age (27%). Sequences were divided into 6 genetic clades (G1-G6). Most (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), and G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 and G4 displayed >2 unique recombinant forms. Rapid turnover of new clades and recombinant forms occurred over time. Clades G1 and G6 dominated in 2018, suggesting the E30 upsurge was caused by emergence of 2 distinct clades circulating in Europe. Investigation into the mechanisms behind the rapid turnover of E30 is crucial for clarifying the epidemiology and evolution of these enterovirus infections.

Faculties and Departments:	05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:	Neher, Richard A
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Centers for Disease Control and Prevention
ISSN:	1080-6040
e-ISSN:	1080-6059
Note:	Publication type according to Uni Basel Research Database: Journal article
Language:	English
Identification Number:	doi: 10.3201/eid2706.203096 pmid: 34013874
edoc DOI:	10.5451/unibas-ep84939
Last Modified:	24 Feb 2022 09:41
Deposited On:	24 Feb 2022 09:41

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